A review of structural modification and biological activities of oleanolic acid

被引：14
作者：
Yang, Huali [1 ,2 ]
Deng, Minghui [2 ]
Jia, Hongwei [2 ]
Zhang, Kaicheng [2 ]
Liu, Yang [2 ]
Cheng, Maosheng [2 ]
Xiao, Wei [1 ]
机构：
[1] Jiangsu Kanion Pharmaceut Co Ltd, State Key Lab New Tech Chinese Med Pharmaceut Proc, State Key Lab New tech Chinese Med Pharmaceut Proc, Lianyungang 222001, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2024年 / 22卷 / 01期
关键词：
Oleanolic acid; Derivatives; Pentacyclic triterpenoid; Structural modification; Biological activities; OXIDE-RELEASING DERIVATIVES; HEPATOCELLULAR-CARCINOMA ACTIVITY; OLEANANE-TYPE TRITERPENES; ACTIVATED PROTEIN-KINASE; IN-VITRO; CANCER-CELLS; ANTIOXIDANT ACTIVITY; ALZHEIMERS-DISEASE; BIOACTIVE SAPONINS; CYTOTOXIC ACTIVITY;
D O I：
10.1016/S1875-5364(24)60559-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Oleanolic acid (OA), a pentacyclic triterpenoid, exhibits a broad spectrum of biological activities, including antitumor, antiviral, antibacterial, anti-inflammatory, hepatoprotective, hypoglycemic, and hypolipidemic effects. Since its initial isolation and identification, numerous studies have reported on the structural modifications and pharmacological activities of OA and its derivatives. Despite this, there has been a dearth of comprehensive reviews in the past two decades, leading to challenges in subsequent research on OA. Based on the main biological activities of OA, this paper comprehensively summarized the modification strategies and structureactivity relationships (SARs) of OA and its derivatives to provide valuable reference for future investigations into OA.
引用
收藏
页码：15 / 30
页数：16
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