Serum proteomic profiling reveals potential inflammatory biomarkers in long-COVID patients: a comparative analysis with healthy controls

被引：0

作者：

Medori, M. C. ^{[1
]}

Dhuli, K. ^{[1
]}

Tezzele, S. ^{[1
]}

Micheletti, C. ^{[1
]}

Maltese, P. E. ^{[1
]}

Cecchin, S. ^{[1
]}

Bonetti, G. ^{[1
,2
]}

Fioretti, F. ^{[3
]}

Calzoni, A. ^{[3
]}

Praderio, A. ^{[3
]}

De Angelis, M. G. ^{[3
]}

Arabia, G. ^{[4
]}

Donato, K. ^{[5
,6
]}

Lorusso, L. ^{[7
]}

Manganotti, P. ^{[8
]}

Capelli, E. ^{[9
,10
]}

Cristoni, S. ^{[11
]}

Nodari, S. ^{[2
]}

Bertelli, M. ^{[1
,5
,6
]}

机构：

[1] MAGIS LAB, Trento, Italy

[2] Univ Perugia, Dept Pharmaceut Sci, Perugia, Italy

[3] Univ & Spedali Civili Brescia, Dept Med & Surg Special, Radiol Sci & Publ Hlth, Brescia, Italy

[4] Univ Brescia, Dept Med & Surg Specialties, Cardiol Unit, Radiol Sci & Publ Hlth, Brescia, Italy

[5] MAGI EUREGIO, Bolzano, Italy

[6] MAGISNAT, Atlanta Tech Pk, Peachtree Corners, GA USA

[7] ASST Lecco, UOC Neurol & Stroke Unit, Merate, Italy

[8] Univ Trieste, Cattinara Univ Hosp ASUGI, Dept Med Surg & Hlth Sci, ASUGI,Clin Unit Neurol, Trieste, Italy

[9] Univ Pavia, Dept Earth & Environm Sci, Pavia, Italy

[10] Univ Pavia, Ctr Hlth Technol, Pavia, Italy

[11] ISB Ion Source & Biotechnol srl, Milan, Italy

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2023年 / 27卷

关键词：

COVID-19; SARS; CoV-2; Sirtuin; 1; Natriuretic Peptide B; Hemopexin; Arachidonate; 5-Lipoxygenase; Transmembrane Protein 1; Mannose Binding Lectin 2; long-COVID syndrome;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: The highly transmissible severe acute respiratory syndrome-Coronavirus-2 was responsible for the 2020 COVID-19 pandemic. COVID-19 mostly affects the respiratory system; however, this infection also affects several other organs. In addition, the sequelae of this disease affect patients for several months after recovery, resulting in long-COVID syndrome. PATIENTS AND METHODS: In order to characterize the differences between healthy control individuals and long-COVID patients, proteomic profiling of the serum of both groups was performed by mass spectrometry. The obtained data were analyzed with multivariate and univariate statistical analyses. RESULTS: Initially, performing a partial latent square discriminant analysis (PLS-DA) made it possible to identify thirty-three proteins of interest, which were then subjected to a receiver operating characteristic (ROC) analysis. Four proteins were identified as potential standalone biomarkers: Sirtuin 1, Natriuretic Peptide B, Hemopexin, and Arachidonate 5-Lipoxygenase. Moreover, a multivariate ROC analysis identified a panel of biomarkers composed of Natriuretic Peptide B, Anterior Gradient 2 Protein, Adiponectin, Endothelin Converting Enzyme 1, Interferon Induced Transmembrane Protein 1, Mannose Binding Lectin 2, Prostaglandin-Endoperoxide Synthase 2, Pirin, Prostaglandin Reductase 1 and Cystatin C. CONCLUSIONS: The identified biomarkers are associated with inflammatory processes, corroborating literature evidence that long-COVID patients develop an inflammatory state that damages many tissues. Nevertheless, these data should be validated in a larger cohort.

引用

页码：1 / 12

页数：12

共 46 条

[1] Dimensionality, psychometric properties, and population-based norms of the Turkish version of the Chalder Fatigue Scale among adults [J].