Involvement of vulva in lichen sclerosus increases the risk of antidepressant and benzodiazepine prescriptions for psychiatric disorder diagnoses

被引：2

作者：

Choi, Una E. ^{[1
]}

Nicholson, Ryan C. ^{[1
]}

Agrawal, Pranjal ^{[1
]}

Watts, Emelia ^{[1
]}

Kohn, Taylor P. ^{[2
]}

Kohn, Jaden R. ^{[3
]}

Clifton, Marisa ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[2] James Buchanan Brady Urol Inst Johns Hopkins, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD USA

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2024年 / 36卷 / 06期

关键词：

QUALITY-OF-LIFE; WOMEN; THERAPY; DEPRESSION;

D O I：

10.1038/s41443-023-00793-3

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

While vulvar lichen sclerosus (VLS) causes intense pruritus, associated risks of mood disorders and prescription patterns and impact of concurrent sexual dysfunction are unknown. We queried TriNetX Diamond Network between 2009 and 2022, conducting three comparisons after propensity-score matching for demographics and relevant comorbidities: (1) women with lichen sclerosus (LS) sparing the vulva vs. women with VLS; (2) VLS patients who received treatment within 6 months of diagnosis vs. patients who did not and (3) VLS patients with vs. without sexual dysfunction. Outcomes included new depressive episodes, anxiety disorder, major depressive disorder (MDD), and prescriptions of antidepressants or benzodiazepines. After matching, VLS was associated with increased depressive episode [risk ratio (RR) 1.39], anxiety disorder (RR 1.93), and MDD (RR 2.00) diagnoses compared to LS sparing the vulva. Next, VLS treatment was associated with decreased risk of depressive episode (RR 0.60) and anxiety disorder (RR 0.72). Finally, concurrent sexual dysfunction was associated with increased benzodiazepine (RR 3.50), vaginal estrogen (RR 6.20), antipruritic agents (RR 3.90), and topical anti-inflammatory (RR 2.61) prescriptions. In conclusion, vulvar involvement is associated with increased risk of antidepressant and benzodiazepine prescriptions, and diagnosis of depressive episode, anxiety disorder, or MDD.

引用

页码：641 / 646

页数：6

共 29 条

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