A nationwide cohort study on incidence and mortality associated with extracranial vascular malformations

被引：11

作者：

Ryu, Jeong Yeop ^{[1
]}

Chang, Yong June ^{[1
]}

Lee, Joon Seok ^{[1
]}

Choi, Kang Young ^{[1
]}

Yang, Jung Dug ^{[1
]}

Lee, Seok-Jong ^{[2
]}

Lee, Jongmin ^{[3
]}

Huh, Seung ^{[4
]}

Kim, Ji Yoon ^{[5
]}

Chung, Ho Yun ^{[1
,6
]}

机构：

[1] Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 680 Gukchaebosanro, Daegu 41405, South Korea

[2] Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea

[3] Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea

[4] Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea

[5] Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea

[6] Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

PORT-WINE STAINS; ARTERIOVENOUS-MALFORMATIONS; VENOUS MALFORMATIONS; NATURAL-HISTORY; HEAD; NECK; CLASSIFICATION; LYMPHANGIOMAS;

D O I：

10.1038/s41598-023-41278-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extracranial vascular malformations are abnormal formations of blood vessels located outside the brain (extracranial) that develop during fetal development. They are caused by errors in the formation of blood vessels in the embryo and can affect various parts of the body, such as the head, neck, face, and other regions. Some malformations may be asymptomatic and only require monitoring, while others may cause significant health issues or cosmetic concerns and may need medical intervention. There are very few studies have investigated the nationwide incidence and quantitative mortality of vascular malformations in terms of their subtypes. Thus, this study aimed to determine the nationwide incidence and mortality associated with vascular malformations. This nationwide population-based study evaluated 70,517 patients with vascular malformations from 2008 to 2021. We evaluated the incidence and mortality associated with each subtype of vascular malformation. Furthermore, Cox regression analysis was used to evaluate the association between vascular malformation and mortality. The annual incidence (per 100,000 population) of overall vascular, venous, capillary, arteriovenous, and lymphatic malformations was 9.85, 1.48, 2.31, 0.24, and 5.82 cases, respectively. Patients with vascular malformations, except those with venous malformations, had higher mortality than the matched controls. Moreover, among the vascular malformation subgroups, the adjusted hazard ratio of mortality was the highest for arteriovenous malformations. This study revealed that the overall annual incidence of vascular malformations was 9.85 cases per 100,000 population in Korea from 2008 to 2021. The mortality of the matched general population was lower than that of patients with vascular malformations, except for those with venous malformations. Additionally, the adjusted hazard ratio for mortality associated with arteriovenous malformations was the highest among the vascular malformation subgroups.

引用

页数：11

共 36 条

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