Wool Keratin Nanofibers for Bioinspired and Sustainable Use in Biomedical Field

被引:23
作者
Ramirez, Diego Omar Sanchez [1 ]
Vineis, Claudia [1 ]
Cruz-Maya, Iriczalli [2 ]
Tonetti, Cinzia [1 ]
Guarino, Vincenzo [2 ]
Varesano, Alessio [1 ]
机构
[1] CNR STIIMA Natl Res Council Inst Intelligent Ind T, Corso Giuseppe Pella 16, I-13900 Biella, Italy
[2] CNR IPCB Natl Res Council Inst Polymers Composites, Mostra,Oltremare,Pad 20,Vle JF Kennedy 54, I-80125 Naples, Italy
关键词
wool keratin; electrospinning; nanofibers; biocompatible; biodegradable; MECHANICAL-PROPERTIES; POLY(BUTYLENE SUCCINATE); MEDICAL IMPLANTS; BIOMATERIALS; DEGRADATION; BIODEGRADABILITY; POLY(L-LACTIDE); PROLIFERATION; REGENERATION; ACID;
D O I
10.3390/jfb14010005
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Keratin is a biocompatible and biodegradable protein as the main component of wool and animal hair fibers. Keratin-based materials support fibroblasts and osteoblasts growth. Keratin has been extracted by sulphitolysis, a green method (no harmful chemicals) with a yield of 38-45%. Keratin has been processed into nanofibers from its solutions by electrospinning. Electrospinning is a versatile and easy-to-use technique to generate nanofibers. It is an eco-friendly and economical method for the production of randomly and uniaxially oriented polymeric nanofibers. Thanks to their high specific surface area, nanofibers have great potential in the biomedical field. Keratin nanofibers have received significant attention in biomedical applications, such as tissue engineering and cell growth scaffolds, for their biocompatibility and bio-functionality. Accordingly, we propose an extensive overview of recent studies focused on the optimization of keratinbased nanofibers, emphasizing their peculiar functions for cell interactions and the role of additive phases in blends or composite systems to particularize them as a function of specific applications (i.e., antibacterial).
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页数:16
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