Engineered nanomedicines for augmenting the efficacy of colorectal cancer immunotherapy

被引：2
作者：
Abdelgalil, Riham M. [1 ,2 ]
Elmorshedy, Yomna M. [1 ,2 ]
Elkhodairy, Kadria A. [1 ,2 ]
Teleb, Mohamed [2 ,3 ]
Bekhit, Adnan A. [2 ,3 ,4 ]
Khattab, Sherine N. [5 ]
Elzoghby, Ahmed O. [1 ,2 ,6 ]
机构：
[1] Alexandria Univ, Fac Pharm, Dept Ind Pharm, Alexandria 21521, Egypt
[2] Alexandria Univ, Fac Pharm, Canc Nanotechnol Res Lab CNRL, Alexandria 21521, Egypt
[3] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt
[4] Univ Bahrain, Coll Hlth & Sport Sci, Allied Hlth Dept, Pharm Program, Riffa 32038, Bahrain
[5] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21521, Egypt
[6] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Boston, MA 02115 USA
来源：
NANOMEDICINE | 2022年 / 17卷 / 22期
关键词：
colorectal cancer; immunotherapy; nanocarriers; nanomedicine; theranostics; DRUG-DELIVERY-SYSTEMS; NANOSTRUCTURED LIPID CARRIERS; VIRUS-LIKE PARTICLES; COLON-CANCER; GRAPHENE OXIDE; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; NANOPARTICLES; CHEMOTHERAPY; ADJUVANT;
D O I：
10.2217/nnm-2022-0214
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Colorectal cancer (CRC) is one of the most devastating diseases worldwide. Immunotherapeutic agents for CRC treatment have shown limited efficacy due to the immunosuppressive tumor microenvironment (TME). In this context, various types of nanoparticles (NPs) have been used to reverse the immunosuppressive TME, potentiate the effect of immunotherapeutic agents and reduce their systemic side effects. Many advantages could be offered by NPs, related to drug-loading efficiency, particle size and others that can potentially aid the delivery of immunotherapeutic agents. The recent research on how nano-based immunotherapy can remodel the immunosuppressive TME of CRC and hence boost the antitumor immune response, as well as the challenges that face clinical translation of NPs and future perspectives, are summarized in this review article.
引用
收藏
页码：1721 / 1745
页数：25
相关论文
共 159 条
  • [61] Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug Delivery
    Lee, Na-Hyun
    You, Sumin
    Taghizadeh, Ali
    Taghizadeh, Mohsen
    Kim, Hye Sung
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (04)
  • [62] Tumour targetable and microenvironment-responsive nanoparticles simultaneously disrupt the PD-1/PD-L1 pathway and MAPK/ERK/JNK pathway for efficient treatment of colorectal cancer
    Li, Yan
    Qi, Ming
    Ding, Feng
    Lv, Yong
    Ma, Jingyu
    Zhu, Yufeng
    [J]. JOURNAL OF DRUG TARGETING, 2021, 29 (04) : 454 - 465
  • [63] EGFR-targeted liposomal nanohybrid cerasomes: theranostic function and immune checkpoint inhibition in a mouse model of colorectal cancer
    Li, Yuan
    Du, Yang
    Liang, Xiaolong
    Sun, Ting
    Xue, Huadan
    Tian, Jie
    Jin, Zhengyu
    [J]. NANOSCALE, 2018, 10 (35) : 16738 - 16749
  • [64] Integrinβ6-Targeted Immunoliposomes Mediate Tumor-Specific Drug Delivery and Enhance Therapeutic Efficacy in Colon Carcinoma
    Liang, Benjia
    Shahbaz, Muhammad
    Wang, Yang
    Gao, Huijie
    Fang, Ruliang
    Niu, Zhengchuan
    Liu, Song
    Wang, Ben
    Sun, Qi
    Niu, Weibo
    Liu, Enyu
    Wang, Jiayong
    Niu, Jun
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (05) : 1183 - 1195
  • [65] A folate receptor-targeted lipoplex delivering interleukin-15 gene for colon cancer immunotherapy
    Liang, Xiao
    Luo, Min
    Wei, Xia-Wei
    Ma, Cui-Cui
    Yang, Yu-Han
    Shao, Bin
    Liu, Yan-Tong
    Liu, Ting
    Ren, Jun
    Liu, Li
    He, Zhi-Yao
    Wei, Yu-Quan
    [J]. ONCOTARGET, 2016, 7 (32) : 52207 - 52217
  • [66] Point-source burst of coordination polymer nanoparticles for tri-modality cancer therapy
    Ling, Xiang
    Han, Wenbo
    Jiang, Xiaomin
    Chen, Xing
    Rodriguez, Megan
    Zhu, Pingping
    Wu, Tong
    Lin, Wenbin
    [J]. BIOMATERIALS, 2021, 270
  • [67] Nano-immunotherapy: Unique mechanisms of nanomaterials in synergizing cancer immunotherapy
    Liu, Quan
    Duo, Yanhong
    Fu, Jianye
    Qiu, Meng
    Sun, Zhe
    Adah, Dickson
    Kang, Jianlong
    Xie, Zhongjian
    Fan, Taojian
    Bao, Shiyun
    Zhang, Han
    Liu, Li-Ping
    Cao, Yihai
    [J]. NANO TODAY, 2021, 36
  • [68] Modified nanoparticle mediated IL-12 immunogene therapy for colon cancer
    Liu, Xiaoxiao
    Gao, Xiang
    Zheng, Songping
    Wang, Bilan
    Li, Yanyan
    Zhao, Chanjuan
    Muftuoglu, Yagmur
    Chen, Song
    Li, Ying
    Yao, Haiyan
    Sun, Hui
    Mao, Qing
    You, Chao
    Guo, Gang
    Wei, Yuquan
    [J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017, 13 (06) : 1993 - 2004
  • [69] Challenges and opportunities in the delivery of cancer therapeutics: update on recent progress
    Lorscheider, Mathilde
    Gaudin, Alice
    Nakhle, Jessica
    Veiman, Kadi-Liis
    Richard, Joel
    Chassaing, Christophe
    [J]. THERAPEUTIC DELIVERY, 2021, 12 (01) : 55 - 76
  • [70] Sustained release of anti-PD-1 peptide for perdurable immunotherapy together with photothermal ablation against primary and distant tumors
    Luo, Lihua
    Yang, Jie
    Zhu, Chunqi
    Jiang, Mengshi
    Guo, Xiaomeng
    Li, Wei
    Yin, Xiaoyi
    Yin, Hang
    Qin, Bin
    Yuan, Xiaoling
    Li, Qingpo
    Du, Yongzhong
    You, Jian
    [J]. JOURNAL OF CONTROLLED RELEASE, 2018, 278 : 87 - 99
234567891011