Engineered nanomedicines for augmenting the efficacy of colorectal cancer immunotherapy

被引：2
作者：
Abdelgalil, Riham M. [1 ,2 ]
Elmorshedy, Yomna M. [1 ,2 ]
Elkhodairy, Kadria A. [1 ,2 ]
Teleb, Mohamed [2 ,3 ]
Bekhit, Adnan A. [2 ,3 ,4 ]
Khattab, Sherine N. [5 ]
Elzoghby, Ahmed O. [1 ,2 ,6 ]
机构：
[1] Alexandria Univ, Fac Pharm, Dept Ind Pharm, Alexandria 21521, Egypt
[2] Alexandria Univ, Fac Pharm, Canc Nanotechnol Res Lab CNRL, Alexandria 21521, Egypt
[3] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt
[4] Univ Bahrain, Coll Hlth & Sport Sci, Allied Hlth Dept, Pharm Program, Riffa 32038, Bahrain
[5] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21521, Egypt
[6] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Boston, MA 02115 USA
来源：
NANOMEDICINE | 2022年 / 17卷 / 22期
关键词：
colorectal cancer; immunotherapy; nanocarriers; nanomedicine; theranostics; DRUG-DELIVERY-SYSTEMS; NANOSTRUCTURED LIPID CARRIERS; VIRUS-LIKE PARTICLES; COLON-CANCER; GRAPHENE OXIDE; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; NANOPARTICLES; CHEMOTHERAPY; ADJUVANT;
D O I：
10.2217/nnm-2022-0214
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Colorectal cancer (CRC) is one of the most devastating diseases worldwide. Immunotherapeutic agents for CRC treatment have shown limited efficacy due to the immunosuppressive tumor microenvironment (TME). In this context, various types of nanoparticles (NPs) have been used to reverse the immunosuppressive TME, potentiate the effect of immunotherapeutic agents and reduce their systemic side effects. Many advantages could be offered by NPs, related to drug-loading efficiency, particle size and others that can potentially aid the delivery of immunotherapeutic agents. The recent research on how nano-based immunotherapy can remodel the immunosuppressive TME of CRC and hence boost the antitumor immune response, as well as the challenges that face clinical translation of NPs and future perspectives, are summarized in this review article.
引用
收藏
页码：1721 / 1745
页数：25
相关论文
共 159 条
  • [91] Targeted exosomes for co-delivery of siFGL1 and siTGF-β1 trigger combined cancer immunotherapy by remodeling immunosuppressive tumor microenvironment
    Pei, Xing
    Zhang, Xiaojuan
    Zhang, Lu
    Yuan, Mengmeng
    Sun, Lu
    Yu, Fei
    Wang, Bangmao
    Zhao, Jingwen
    He, Huining
    Yang, Victor C.
    [J]. CHEMICAL ENGINEERING JOURNAL, 2021, 421
  • [92] Downstream processing of triple layered rotavirus like particles
    Peixoto, C.
    Sousa, M. F. Q.
    Silva, A. C.
    Carrondo, M. J. T.
    Alves, P. M.
    [J]. JOURNAL OF BIOTECHNOLOGY, 2007, 127 (03) : 452 - 461
  • [93] Polymer nanoparticles: Preparation techniques and size-control parameters
    Rao, J. Prasad
    Geckeler, Kurt E.
    [J]. PROGRESS IN POLYMER SCIENCE, 2011, 36 (07) : 887 - 913
  • [94] The challenges of oral drug delivery via nanocarriers
    Reinholz, Jonas
    Landfester, Katharina
    Mailaender, Volker
    [J]. DRUG DELIVERY, 2018, 25 (01) : 1694 - 1705
  • [95] Biomimetic Glyconanoparticle Vaccine for Cancer Immunotherapy
    Reuven, Eliran Moshe
    Ben-Arye, Shani Leviatan
    Yu, Hai
    Duchi, Roberto
    Perota, Andrea
    Conchon, Sophie
    Abramovitch, Shirley Bachar
    Soulillou, Jean-Paul
    Galli, Cesare
    Chen, Xi
    Padler-Karavani, Vered
    [J]. ACS NANO, 2019, 13 (03) : 2936 - 2947
  • [96] The application of nano-medicine to overcome the challenges related to immune checkpoint blockades in cancer immunotherapy: Recent advances and opportunities
    Sanaei, Mohammad-Javad
    Pourbagheri-Sigaroodi, Atieh
    Kaveh, Vahid
    Sheikholeslami, Seyed Amir
    Salari, Sina
    Bashash, Davood
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2021, 157
  • [97] Hemocompatibility and Macrophage Response of Pristine and Functionalized Graphene
    Sasidharan, Abhilash
    Panchakarla, Leela S.
    Sadanandan, Aparna R.
    Ashokan, Anusha
    Chandran, Parwathy
    Girish, Chundayil Madathil
    Menon, Deepthy
    Nair, Shantikumar V.
    Rao, C. N. R.
    Koyakutty, Manzoor
    [J]. SMALL, 2012, 8 (08) : 1251 - 1263
  • [98] Synthetic HDL Nanoparticles Delivering Docetaxel and CpG for Chemoimmunotherapy of Colon Adenocarcinoma
    Scheetz, Lindsay M.
    Yu, Minzhi
    Li, Dan
    Castro, Maria G.
    Moon, James J.
    Schwendeman, Anna
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (05)
  • [99] Sentovich SM., 2019, ASCRS MANUAL COLON R, P443
  • [100] Toxicity and Genotoxicity of Nano-SiO2 on Human Epithelial Intestinal HT-29 Cell Line
    Sergent, Jacques-Aurelien
    Paget, Vincent
    Chevillard, Sylvie
    [J]. ANNALS OF OCCUPATIONAL HYGIENE, 2012, 56 (05) : 622 - 630
567891011121314