Engineered nanomedicines for augmenting the efficacy of colorectal cancer immunotherapy

被引：2
作者：
Abdelgalil, Riham M. [1 ,2 ]
Elmorshedy, Yomna M. [1 ,2 ]
Elkhodairy, Kadria A. [1 ,2 ]
Teleb, Mohamed [2 ,3 ]
Bekhit, Adnan A. [2 ,3 ,4 ]
Khattab, Sherine N. [5 ]
Elzoghby, Ahmed O. [1 ,2 ,6 ]
机构：
[1] Alexandria Univ, Fac Pharm, Dept Ind Pharm, Alexandria 21521, Egypt
[2] Alexandria Univ, Fac Pharm, Canc Nanotechnol Res Lab CNRL, Alexandria 21521, Egypt
[3] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt
[4] Univ Bahrain, Coll Hlth & Sport Sci, Allied Hlth Dept, Pharm Program, Riffa 32038, Bahrain
[5] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21521, Egypt
[6] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Boston, MA 02115 USA
来源：
NANOMEDICINE | 2022年 / 17卷 / 22期
关键词：
colorectal cancer; immunotherapy; nanocarriers; nanomedicine; theranostics; DRUG-DELIVERY-SYSTEMS; NANOSTRUCTURED LIPID CARRIERS; VIRUS-LIKE PARTICLES; COLON-CANCER; GRAPHENE OXIDE; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; NANOPARTICLES; CHEMOTHERAPY; ADJUVANT;
D O I：
10.2217/nnm-2022-0214
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Colorectal cancer (CRC) is one of the most devastating diseases worldwide. Immunotherapeutic agents for CRC treatment have shown limited efficacy due to the immunosuppressive tumor microenvironment (TME). In this context, various types of nanoparticles (NPs) have been used to reverse the immunosuppressive TME, potentiate the effect of immunotherapeutic agents and reduce their systemic side effects. Many advantages could be offered by NPs, related to drug-loading efficiency, particle size and others that can potentially aid the delivery of immunotherapeutic agents. The recent research on how nano-based immunotherapy can remodel the immunosuppressive TME of CRC and hence boost the antitumor immune response, as well as the challenges that face clinical translation of NPs and future perspectives, are summarized in this review article.
引用
收藏
页码：1721 / 1745
页数：25
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