Development of variant-proof severe acute respiratory syndrome coronavirus 2, pan-sarbecovirus, and pan-β-coronavirus vaccines

被引：2

作者：

Zhou, Jie ^{[1
]}

Liu, Zezhong ^{[1
,2
]}

Zhang, Guangxu ^{[1
]}

Xu, Wei ^{[1
]}

Xing, Lixiao ^{[1
]}

Lu, Lu ^{[1
]}

Wang, Qian ^{[1
]}

Jiang, Shibo ^{[1
]}

机构：

[1] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Sch Basic Med Sci, Key Lab Med Mol Virol MOE NHC CAMS, Shanghai 200032, Peoples R China

[2] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2023年 / 95卷 / 01期

基金：

中国国家自然科学基金;

关键词：

COVID-19; pan-sarbecovirus; pan-beta-coronavirus; RBD; SARS-CoV-2; vaccines; RECEPTOR-BINDING DOMAIN; SPIKE PROTEIN; SARS-COV; NEUTRALIZING ANTIBODIES; NANOPARTICLE VACCINES; SARS-COV-2; INFECTION; BAT CORONAVIRUSES; CONSERVED SITE; S PROTEIN; IMMUNOGENICITY;

D O I：

10.1002/jmv.28172

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with high transmission rates and striking immune evasion have posed a serious challenge to the application of current first-generation SARS-CoV-2 vaccines. Other sarbecoviruses, such as SARS-CoV and SARS-related coronaviruses (SARSr-CoVs), have the potential to cause outbreaks in the future. These facts call for the development of variant-proof SARS-CoV-2, pan-sarbecovirus or pan-beta-CoV vaccines. Several novel vaccine platforms have been used to develop vaccines with broad-spectrum neutralizing antibody responses and protective immunity to combat the current SARS-CoV-2 and its variants, other sarbecoviruses, as well as other beta-CoVs, in the future. In this review, we discussed the major target antigens and protective efficacy of current SARS-CoV-2 vaccines arid summarized recent advances in broad-spectrum vaccines against sarbecoviruses and beta-CoVs.

引用

页数：19

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