Treatment of congenital Langerhans cell histiocytosis with cobimetinib

被引：2
作者：
Benjelloun, Ghita [1 ]
Roquet-Gravy, Charlotte [2 ]
Marot, Liliane [3 ]
Secco, Leo-Paul [3 ]
Roquet-Gravy, Pierre-Paul [1 ]
Baeck, Marie [2 ]
Bulinckx, Audrey [1 ,4 ]
机构：
[1] Grand Hop Charleroi, Dept Dermatol, Charleroi, Belgium
[2] Clin Univ St Luc, Dept Dermatol, Brussels, Belgium
[3] Clin Univ St Luc, Dept Anatomopathol, Brussels, Belgium
[4] Grand Hop Charleroi, Dept Dermatol, GrandRue 3, B-6000 Charleroi, Belgium
来源：
PEDIATRIC DERMATOLOGY | 2024年 / 41卷 / 03期
关键词：
BRAF V600E mutation; cobimetinib; congenital Langerhans cell histiocytosis; MEK mutation; BRAF; MUTATIONS; DISEASE; MAP2K1;
D O I：
10.1111/pde.15512
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report a case of congenital multisystem Langerhans cell histiocytosis with cutaneous and hematopoietic involvement. After the failure of first-line (vinblastine and prednisolone) and second-line (vincristine and cytarabine) therapies, treatment with cobimetinib, a mitogen-activated protein kinase (MEK) inhibitor, led to the remission of disease and a sustained response after 11 months of ongoing treatment. Protein kinase inhibitors targeting BRAF or MEK could represent a promising future therapeutic option, also in children with LCH.
引用
收藏
页码：515 / 517
页数：3
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