Treatment of congenital Langerhans cell histiocytosis with cobimetinib

被引：2

作者：

Benjelloun, Ghita ^{[1
]}

Roquet-Gravy, Charlotte ^{[2
]}

Marot, Liliane ^{[3
]}

Secco, Leo-Paul ^{[3
]}

Roquet-Gravy, Pierre-Paul ^{[1
]}

Baeck, Marie ^{[2
]}

Bulinckx, Audrey ^{[1
,4
]}

机构：

[1] Grand Hop Charleroi, Dept Dermatol, Charleroi, Belgium

[2] Clin Univ St Luc, Dept Dermatol, Brussels, Belgium

[3] Clin Univ St Luc, Dept Anatomopathol, Brussels, Belgium

[4] Grand Hop Charleroi, Dept Dermatol, GrandRue 3, B-6000 Charleroi, Belgium

来源：

PEDIATRIC DERMATOLOGY | 2024年 / 41卷 / 03期

关键词：

BRAF V600E mutation; cobimetinib; congenital Langerhans cell histiocytosis; MEK mutation; BRAF; MUTATIONS; DISEASE; MAP2K1;

D O I：

10.1111/pde.15512

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We report a case of congenital multisystem Langerhans cell histiocytosis with cutaneous and hematopoietic involvement. After the failure of first-line (vinblastine and prednisolone) and second-line (vincristine and cytarabine) therapies, treatment with cobimetinib, a mitogen-activated protein kinase (MEK) inhibitor, led to the remission of disease and a sustained response after 11 months of ongoing treatment. Protein kinase inhibitors targeting BRAF or MEK could represent a promising future therapeutic option, also in children with LCH.

引用

页码：515 / 517

页数：3

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