Emerging synthetic strategies and pharmacological insights of 1,3,4-thiadiazole derivatives: a comprehensive review

被引：7

作者：

Kumar, Davinder ^{[1
]}

Aggarwal, Navidha ^{[2
]}

Kumar, Virender ^{[1
]}

Chopra, Hitesh ^{[3
]}

Marwaha, Rakesh Kumar ^{[1
]}

Sharma, Rohit ^{[4
]}

机构：

[1] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, India

[2] Maharishi Markandeshwar Deemed Univ, MM Coll Pharm, Mullana 133207, India

[3] Saveetha Inst Med & Tech Sci, Saveetha Sch Engn, Dept Biosci, Chennai 602105, Tamil Nadu, India

[4] Banaras Hindu Univ, Inst Med Sci, Fac Ayurveda, Dept Rasa Shastra & Bhaishajya Kalpana, Varanasi 221005, Uttar Pradesh, India

来源：

FUTURE MEDICINAL CHEMISTRY | 2024年 / 16卷 / 06期

关键词：

1,3,4-thiadiazole; chemical reactions; heterocyclic chemistry; pharmacological activities; synthesis; BIOLOGICAL EVALUATION; IN-VITRO; MOLECULAR DOCKING; THIADIAZOLE; 1,2,4-TRIAZOLE; CYTOTOXICITY; INHIBITORS; MOIETY; POTENT; SILICO;

D O I：

10.4155/fmc-2023-0203

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review meticulously examines the synthesis techniques for 1,3,4-thiadiazole derivatives, focusing on cyclization, condensation reactions and functional group transformations. It enhances the understanding of these chemical methods that re crucial for tailoring derivative properties and functionalities. This study is considered to be vital for researchers, detailing established effects such as antioxidant, antimicrobial and anticancer activities, and revealing emerging pharmacological potentials such as neuroprotective, antiviral and antidiabetic properties. It also discusses the molecular mechanisms underlying these effects. In addition, this article covers structure-activity relationship studies and computational modelling that are essential for designing potent, selective 1,3,4-thiadiazole compounds. This work lays a foundation for future research and targeted therapeutic development.

引用

页码：563 / 581

页数：20

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