Longitudinal reduction in brain volume in patients with schizophrenia and its association with cognitive function

被引：2

作者：

Yamazaki, Ryuichi ^{[1
,2
]}

Matsumoto, Junya ^{[1
]}

Ito, Satsuki ^{[1
,3
]}

Nemoto, Kiyotaka ^{[4
]}

Fukunaga, Masaki ^{[5
]}

Hashimoto, Naoki ^{[6
]}

Kodaka, Fumitoshi ^{[1
,2
]}

Takano, Harumasa ^{[7
]}

Hasegawa, Naomi ^{[1
]}

Yasuda, Yuka ^{[1
,8
]}

Fujimoto, Michiko ^{[1
,9
]}

Yamamori, Hidenaga ^{[1
,9
,10
]}

Watanabe, Yoshiyuki ^{[11
]}

Miura, Kenichiro ^{[1
]}

Hashimoto, Ryota ^{[1
]}

机构：

[1] Natl Inst Mental Hlth, Natl Ctr Neurol & Psychiat, Dept Pathol Mental Dis, Kodaira, Japan

[2] Jikei Univ, Sch Med, Dept Psychiat, Tokyo, Japan

[3] Ochanomizu Univ, Grad Sch Humanity & Sci, Dept Dev & Clin Psychol, Div Human Dev Sci, Tokyo, Japan

[4] Univ Tsukuba, Inst Med, Dept Psychiat, Tsukuba, Japan

[5] Natl Inst Physiol Sci, Sect Brain Funct Informat, Okazaki, Japan

[6] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Sapporo, Japan

[7] Natl Ctr Neurol & Psychiat, Dept Clin Neuroimaging, Integrat Brain Imaging Ctr, Kodaira, Tokyo, Japan

[8] Med Corp Foster, Life Grow Brilliant Mental Clin, Osaka, Japan

[9] Osaka Univ, Grad Sch Med, Dept Psychiat, Suita, Japan

[10] Japan Community Hlth Care Org Osaka Hosp, Osaka, Japan

[11] Shiga Univ Med Sci, Dept Radiol, Otsu, Japan

来源：

NEUROPSYCHOPHARMACOLOGY REPORTS | 2024年 / 44卷 / 01期

基金：

日本学术振兴会;

关键词：

biomarker; cognitive decline; longitudinal study; schizophrenia; structural MRI; SYMPTOM DIMENSIONS; 1ST-EPISODE SCHIZOPHRENIA; NEUROLEPTIC-NAIVE; METAANALYSIS; PSYCHOSIS; DEFICITS; PERFORMANCE; MORPHOLOGY; SEVERITY; IMPACT;

D O I：

10.1002/npr2.12423

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Establishing a brain biomarker for schizophrenia is strongly desirable not only to support diagnosis by psychiatrists but also to help track the progressive changes in the brain over the course of the illness. A brain morphological signature of schizophrenia was reported in a recent study and is defined by clusters of brain regions with reduced volume in schizophrenia patients compared to healthy individuals. This signature was proven to be effective at differentiating patients with schizophrenia from healthy individuals, suggesting that it is a good candidate brain biomarker of schizophrenia. However, the longitudinal characteristics of this signature have remained unclear. In this study, we examined whether these changes occurred over time and whether they were associated with clinical outcomes. We found a significant change in the brain morphological signature in schizophrenia patients with more brain volume loss than the natural, age-related reduction in healthy individuals, suggesting that this change can capture a progressive morphological change in the brain. We further found a significant association between changes in the brain morphological signature and changes in the full-scale intelligence quotient (IQ). The patients with IQ improvement showed preserved brain morphological signatures, whereas the patients without IQ improvement showed progressive changes in the brain morphological signature, suggesting a link between potential recovery of intellectual abilities and the speed of brain pathology progression. We conclude that the brain morphological signature is a brain biomarker that can be used to evaluate progressive changes in the brain that are associated with cognitive impairment due to schizophrenia. The brain morphological signature defined by clusters of brain regions with reduced volume in patients with schizophrenia compared to healthy individuals is a brain biomarker that can be used to evaluate progressive changes in the brain. The changes in the signature are associated with cognitive impairments due to schizophrenia.image

引用

页码：206 / 215

页数：10

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