Taming Postoperative Delirium with Dexmedetomidine: A Review of the Therapeutic Agent's Neuroprotective Effects following Surgery

被引：4
作者：
Bargnes, Vincent, III [1 ]
Oliver, Brian [1 ]
Wang, Emily [2 ]
Greenspan, Seth [1 ]
Jin, Zhaosheng [1 ]
Yeung, Isaac [1 ]
Bergese, Sergio [1 ]
机构：
[1] Stony Brook Univ Hosp, Dept Anesthesiol, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Renaissance Sch Med, Stony Brook, NY 11794 USA
来源：
PHARMACEUTICALS | 2023年 / 16卷 / 10期
关键词：
postoperative delirium; dexmedetomidine; perioperative neurocognitive disorder; neuroprotection; TRIAL SEQUENTIAL-ANALYSIS; COGNITIVE DYSFUNCTION; ELDERLY-PATIENTS; CARDIAC-SURGERY; PERIOPERATIVE DEXMEDETOMIDINE; CEREBRAL-ISCHEMIA; OLDER PATIENTS; RISK-FACTORS; OFF-PUMP; ANESTHESIA;
D O I：
10.3390/ph16101453
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Postoperative delirium (POD) represents a perioperative neurocognitive disorder that has dreaded ramifications on a patient's recovery from surgery. Dexmedetomidine displays multiple mechanisms of neuroprotection to assist in preventing POD as a part of a comprehensive anesthetic care plan. This review will cover dexmedetomidine's pharmacological overlap with the current etiological theories behind POD along with pre-clinical and clinical studies on POD prevention with dexmedetomidine. While the body of evidence surrounding the use of dexmedetomidine for POD prevention still requires further development, promising evidence exists for the use of dexmedetomidine in select dosing and circumstances to enhance recovery from surgery.
引用
收藏
页数：17
相关论文
共 87 条
  • [1] Epidemiology of Peripheral Artery Disease and Polyvascular Disease
    Aday, Aaron W.
    Matsushita, Kunihiro
    [J]. CIRCULATION RESEARCH, 2021, 128 (12) : 1818 - 1832
  • [2] American Psychiatric Association A, 1994, DIAGNOSTIC STAT MANU, DOI [10.1176/appi.books.9780890425596, DOI 10.1176/APPI.BOOKS.9780890425596]
  • [3] Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study
    Ballweg, Tyler
    White, Marissa
    Parker, Margaret
    Casey, Cameron
    Bo, Amber
    Farahbakhsh, Zahra
    Kayser, Austin
    Blair, Alexander
    Lindroth, Heidi
    Pearce, Robert A.
    Blennow, Kaj
    Zetterberg, Henrik
    Lennertz, Richard
    Sanders, Robert D.
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2021, 126 (02) : 458 - 466
  • [4] Addition of dexmedetomidine to benzodiazepines for patients with alcohol withdrawal syndrome in the intensive care unit: a randomized controlled study
    Bielka, Kateryna
    Kuchyn, Iurii
    Glumcher, Felix
    [J]. ANNALS OF INTENSIVE CARE, 2015, 5
  • [5] Postoperative cognitive dysfunction in clinical practice
    Brodier, E. A.
    Cibelli, M.
    [J]. BJA EDUCATION, 2021, 21 (02) : 75 - 82
  • [6] Dexmedetomidine may impair cognitive testing during endovascular embolization of cerebral arteriovenous malformations: A retrospective case report series
    Bustillo, MA
    Lazar, RM
    Finck, AD
    Fitzsimmons, B
    Berman, MF
    Pile-Spellman, J
    Heyer, EJ
    [J]. JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2002, 14 (03) : 209 - 212
  • [7] Outcomes of patients with antiphospholipid syndrome after pulmonary endarterectomy
    Camous, Julien
    Decrombecque, Thibaut
    Louvain-Quintard, Virginie
    Doubine, Sylvie
    Dartevelle, Philippe
    Stephan, Francois
    [J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2014, 46 (01) : 116 - 120
  • [8] BIS-guided Anesthesia Decreases Postoperative Delirium and Cognitive Decline
    Chan, Matthew T. V.
    Cheng, Benny C. P.
    Lee, Tatia M. C.
    Gin, Tony
    [J]. JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2013, 25 (01) : 33 - 42
  • [9] Intraoperative Glycemic Variability and Mean Glucose are Predictors for Postoperative Delirium After Cardiac Surgery: A Retrospective Cohort Study
    Choi, Hoon
    Park, Chul Soo
    Huh, Jaewon
    Koo, Jungmin
    Jeon, Joonpyo
    Kim, Eunsung
    Jung, Sangmin
    Kim, Hwan Wook
    Lim, Ju Yong
    Hwang, Wonjung
    [J]. CLINICAL INTERVENTIONS IN AGING, 2022, 17 : 79 - 95
  • [10] Efficacy and safety of sedation with dexmedetomidine in critical care patients: A meta-analysis of randomized controlled trials
    Constantin, Jean-Michel
    Momon, Aurelien
    Mantz, Jean
    Payen, Jean-Francois
    De Jonghe, Bernard
    Perbet, Sebastien
    Cayot, Sophie
    Chanques, Gerald
    Perreira, Bruno
    [J]. ANAESTHESIA CRITICAL CARE & PAIN MEDICINE, 2016, 35 (01) : 7 - 15
123456789