Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis

被引：0

作者：

Bashir, Sania ^{[1
]}

Qamar, Fatima ^{[1
,4
]}

Naveed, Safila ^{[1
]}

Zainab, Syeda ^{[2
]}

Sadia, Halima ^{[1
]}

Sana, Aisha ^{[1
]}

Muzafar, Wajeeha ^{[3
]}

机构：

[1] Jinnah Univ Women, Fac Pharm, Dept Pharmaceut Chem, Karachi, Pakistan

[2] Jinnah Univ Women, Dept Pharmaceut, Karachi, Pakistan

[3] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Dept Chem, Karachi, Pakistan

[4] Jinnah Univ Women, Fac Pharm, Karachi, Pakistan

来源：

INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH | 2023年 / 57卷 / 04期

关键词：

Moxifloxacin; Glimepiride; Glibenclamide; in vitro interaction studies; PERFORMANCE LIQUID-CHROMATOGRAPHY; LEVOFLOXACIN; METFORMIN; PIOGLITAZONE; VALIDATION;

D O I：

10.5530/ijper.57.4.146

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation. Materials and Methods: Mediterranean C-18 column with dimensions of 150mmx4.6mm was used with HPLC Shimadzu_ LC-20 AT model, Version 1:62 is used for processing of chromatograms at room temperature (25 +/- 2degree celsius). 1 mL per minute was the flow rate and detector were set at 254nm with mobile Phase consisting of 85:10:5 v/v methanol: water: acetonitrile. Results: The developed method proved to be accurate, simple, effective precise and reproducible. One way ANOVA was also applied for further confirmation of the results. Conclusion:The method is applicable for the routine analysis of drugs in API and in formulation and for studying in vitro interaction studies.

引用

页码：1226 / 1231

页数：6

共 50 条

[31] Effects of oral anti-diabetic drugs on bone
Lafage-Proust, Marie-Helene
OSTEOPOROSIS INTERNATIONAL, 2013, 24 : S461 - +
[32] Green RP-HPLC method for simultaneous determination of moxifloxacin combinations: Investigation of the greenness for the proposed method
Ibrahim, Fawzia A.
Elmansi, Heba
Fathy, Mona E.
MICROCHEMICAL JOURNAL, 2019, 148 : 151 - 161
[33] Validated HPTLC and Stability Indicating RP-HPLC Methods for the Simultaneous Estimation of Moxifloxacin and Dexamethasone in Bulk and Ophthalmic Dosage Form
Gandhi, B. Mohan
Rao, A. Lakshmana
Rao, J. Venkateswara
ORIENTAL JOURNAL OF CHEMISTRY, 2016, 32 (04) : 2059 - 2072
[34] RP-HPLC Analysis of Temozolomide in Pharmaceutical Dosage Forms
Rao, A. Lakshmana
Ramesh, G. Taraka
Rao, J. V. L. N. S.
ASIAN JOURNAL OF CHEMISTRY, 2010, 22 (07) : 5067 - 5071
[35] RP-HPLC ANALYSIS OF HYDROPHOBIC ALENDRONATE AMIDATED DERIVATIVES
Lu, Ting Li
Hu, Hui Jing
Zhao, Wen
Chen, Tao
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 2010, 33 (03) : 349 - 361
[36] Rapid Analysis of Glibenclamide Using an Environmentally Benign Stability-Indicating RP-HPLC Method
Haq, Nazrul
Alanazi, Fars Kaed
Alsarra, Ibrahim Abdullah
Shakeel, Faiyaz
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 13 (03): : 863 - 872
[37] RP-HPLC Analysis and Antidiabetic Activity of Swertia paniculata
Negi, Jagmohan S.
Singh, Pramod
Joshi nee Pant, Geeta
Rawat, Mohan S. M.
NATURAL PRODUCT COMMUNICATIONS, 2010, 5 (06) : 907 - 910
[38] SIMVASTATIN ASSAY AND DISSOLUTION STUDIES BY FEASIBLE RP-HPLC IN TABLETS
Marques-Marinho, Flavia Dias
dos Santos, Amanda Leao
Vianna-Soares, Cristina Duarte
Reis, Ilka Afonso
da Costa Zanon, Jose Carlos
Lima, Angelica Alves
QUIMICA NOVA, 2012, 35 (06): : 1233 - 1238
[39] The Effects of Anti-Diabetic Drugs on LDL Subclasses: Any Role for Colesevelam?
Rizzo, Manfredi
Mikhailidis, Dimitri P.
Al-Rasadi, Khalid
CARDIOVASCULAR DRUGS AND THERAPY, 2014, 28 (03) : 205 - 207
[40] Bone Effects of Glitazones and Other Anti-Diabetic Drugs
Rejnmark, Lars
CURRENT DRUG SAFETY, 2008, 3 (03) : 194 - 198

← 1 2 3 4 5 →