Genetic effects in a progressive model of parkinsonism induced by reserpine

被引：1

作者：

Fadanni, Guilherme Pasetto ^{[1
]}

Leao, Anderson Henrique Franca Figueiredo ^{[2
]}

Granzotto, Natalli ^{[1
]}

Pereira, Aline Guimaraes ^{[3
]}

de Gois, Auderlan Mendonca ^{[4
]}

Anjos, Pamela Andressa Ramborger ^{[1
]}

Linder, Aurea Elizabeth ^{[1
]}

Santos, Jose Ronaldo ^{[4
]}

Silva, Regina Helena ^{[2
]}

Izidio, Geison Souza ^{[1
,3
,5
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Biol Sci, Grad Program Pharmacol, Florianopolis, SC, Brazil

[2] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil

[3] Univ Fed Santa Catarina, Ctr Biol Sci, Grad Program Dev & Cellular Biol, Florianopolis, SC, Brazil

[4] Univ Fed Sergipe, Dept Biosci, Lab Behav & Evolutionary Neurobiol, Itabaiana, Brazil

[5] Univ Fed Santa Catarina, Biol Sci Ctr, Cellular Biol Embryol & Genet Dept, Behav Genet Lab, BR-88040900 Florianopolis, SC, Brazil

来源：

PSYCHOPHARMACOLOGY | 2023年 / 240卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

Parkinson's disease; SHR; Oral dyskinesia; Tyrosine hydroxylase; Blood pressure; ANXIETY-RELATED BEHAVIORS; ALPHA-SYNUCLEIN; ANIMAL-MODELS; PPAR-GAMMA; DISEASE; DOPAMINE; MOTOR; IDENTIFICATION; MUTATION; DEFICITS;

D O I：

10.1007/s00213-023-06350-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective and methodsWe investigated the locomotor, emotional, physiological, and neurobiological effects induced by low-dose reserpine repeated treatment (0.1 mg/kg; 14 injections) in males from the Lewis (LEW), Spontaneously Hypertensive Rats (SHR), and SHR.LEW-(D4Rat76-D4Mgh11) (SLA16) isogenic rat strains, which have different genetic backgrounds on chromosome 4. Behavioral responses in the catalepsy, open-field, and oral movements' tests were coupled with blood pressure, body weight, and striatal tyrosine hydroxylase (TH) level assessments to establish neurobiological comparisons between reserpine-induced impairments and genetic backgroundsResultsResults revealed the SHR strain was more sensitive in the catalepsy test and exhibited higher TH immunoreactivity in the dorsal striatum. The SLA16 strain presented more oral movements, suggesting increased susceptibility to develop oral dyskinesia.ConclusionsOur results showed the efficacy of repeated treatment with a low dose of reserpine and demonstrated, for the first time, the genetic influence of a specific region of chromosome 4 on the expression of these effects.

引用

页码：1131 / 1142

页数：12

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