Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes

被引：28

作者：

Pang, Huiwen ^{[1
]}

Huang, Xiangquan ^{[1
]}

Xu, Zhi Ping ^{[1
]}

Chen, Chen ^{[2
]}

Han, Felicity Y. ^{[1
]}

机构：

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld, Australia

[2] Univ Queensland, Fac Med, Sch Biomed Sci, Brisbane, Qld, Australia

来源：

DRUG DISCOVERY TODAY | 2023年 / 28卷 / 01期

关键词：

Oral insulin; Poly(lactic co-glycolic acid) (PLGA); Biological barriers; Mucus; Epithelium; Gastrointestinal tract (GIT); CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; INTRACELLULAR FATE; IN-VITRO; MUCUS; CHITOSAN; SECRETION; PEG; ABSORPTION;

D O I：

10.1016/j.drudis.2022.103393

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Currently, the only practical way to treat type 1 and advanced insulin-dependent type 2 diabetes mellitus (T1/2DM) is the frequent subcutaneous injection of insulin, which is significantly different physiologically from endogenous insulin secretion from pancreatic islets and can lead to hyperinsu-linemia, pain, and infection in patients with poor compliance. Hence, oral insulin delivery has been actively pursued to revolutionize the treatment of insulin-dependent diabetes. In this review, we provide an overview of recent progress in developing poly(lactic co-glycolic acid) (PLGA) nanoparticles (NPs) for oral insulin delivery. Different strategies for insulin-loaded PLGA NPs to achieve normo-glycemic effects are discussed. Finally, challenges and future perspectives of PLGA NPs for oral insulin delivery are put forward.

引用

页码：14 / 14

页数：1

共 50 条

[31] pH-sensitive thiolated nanoparticles facilitate the oral delivery of insulin in vitro and in vivo
Zhang, Yan
Lin, Xia
Du, Xuli
Geng, Sicong
Li, Hongren
Sun, Hong
Tang, Xing
Xiao, Wei
[J]. JOURNAL OF NANOPARTICLE RESEARCH, 2015, 17 (02) : 1 - 11
[32] Polymeric nanoparticles (PNPs) for oral delivery of insulin
Wang, Yunyun
Li, Hao
Rasool, Aamir
Wang, Hebin
Manzoor, Robina
Zhang, Genlin
[J]. JOURNAL OF NANOBIOTECHNOLOGY, 2024, 22 (01)
[33] Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment
Mumuni, Momoh A.
Kenechukwu, Franklin C.
Ofokansi, Kenneth C.
Attama, Anthony A.
Diaz, David Diaz
[J]. CARBOHYDRATE POLYMERS, 2020, 229
[34] Surface-modified PLGA nanoparticles with chitosan for oral delivery of tolbutamide
Shi, Yongli
Xue, Jintao
Jia, Liyun
Du, Qian
Niu, Jie
Zhang, Dongyang
[J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 161 : 67 - 72
[35] Advances in buccal and oral delivery of insulin
Elsayed, Amani
Al-Remawi, Mayyas
Jaber, Nisrein
Abu-Salah, Khalid M.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 633
[36] Intestinal micropatches for oral insulin delivery
Banerjee, Amrita
Wong, Jessica
Gogoi, Rohan
Brown, Tyler
Mitragotri, Samir
[J]. JOURNAL OF DRUG TARGETING, 2017, 25 (07) : 608 - 615
[37] Selenium nanoparticles as versatile carriers for oral delivery of insulin: Insight into the synergic antidiabetic effect and mechanism
Deng, Wenji
Xie, Qian
Wang, Huan
Ma, Zhiguo
Wu, Baojian
Zhang, Xingwang
[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017, 13 (06) : 1965 - 1974
[38] Strategies for effective oral insulin delivery with modified chitosan nanoparticles: A review
Mukhopadhyay, Piyasi
Mishra, Roshnara
Rana, Dipak
Kundu, Patit P.
[J]. PROGRESS IN POLYMER SCIENCE, 2012, 37 (11) : 1457 - 1475
[39] Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
Jin, Yun
Song, Yupin
Zhu, Xi
Zhou, Dan
Chen, Chunhui
Zhang, Zhirong
Huang, Yuan
[J]. BIOMATERIALS, 2012, 33 (05) : 1573 - 1582
[40] A novel ligand conjugated nanoparticles for oral insulin delivery
Liu, Chong
Shan, Wei
Liu, Min
Zhu, Xi
Xu, Juan
Xu, Yining
Huang, Yuan
[J]. DRUG DELIVERY, 2016, 23 (06) : 2015 - 2025

← 1 2 3 4 5 →