Progress in oral insulin delivery by PLGA nanoparticles for the management of diabetes

被引：28
作者：
Pang, Huiwen [1 ]
Huang, Xiangquan [1 ]
Xu, Zhi Ping [1 ]
Chen, Chen [2 ]
Han, Felicity Y. [1 ]
机构：
[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld, Australia
[2] Univ Queensland, Fac Med, Sch Biomed Sci, Brisbane, Qld, Australia
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 01期
关键词：
Oral insulin; Poly(lactic co-glycolic acid) (PLGA); Biological barriers; Mucus; Epithelium; Gastrointestinal tract (GIT); CELL-PENETRATING PEPTIDES; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; INTRACELLULAR FATE; IN-VITRO; MUCUS; CHITOSAN; SECRETION; PEG; ABSORPTION;
D O I：
10.1016/j.drudis.2022.103393
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Currently, the only practical way to treat type 1 and advanced insulin-dependent type 2 diabetes mellitus (T1/2DM) is the frequent subcutaneous injection of insulin, which is significantly different physiologically from endogenous insulin secretion from pancreatic islets and can lead to hyperinsu-linemia, pain, and infection in patients with poor compliance. Hence, oral insulin delivery has been actively pursued to revolutionize the treatment of insulin-dependent diabetes. In this review, we provide an overview of recent progress in developing poly(lactic co-glycolic acid) (PLGA) nanoparticles (NPs) for oral insulin delivery. Different strategies for insulin-loaded PLGA NPs to achieve normo-glycemic effects are discussed. Finally, challenges and future perspectives of PLGA NPs for oral insulin delivery are put forward.
引用
收藏
页码：14 / 14
页数：1
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