Non-Coding RNAs as Key Regulators in Lung Cancer

被引：10

作者：

Gilyazova, Irina ^{[1
,2
]}

Gimalova, Galiya ^{[1
,2
]}

Nizamova, Aigul ^{[1
]}

Galimova, Elmira ^{[3
]}

Ishbulatova, Ekaterina ^{[2
]}

Pavlov, Valentin ^{[4
]}

Khusnutdinova, Elza ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Ufa Fed Res Ctr, Inst Biochem & Genet, Ufa 450054, Russia

[2] Bashkir State Med Univ, Inst Urol & Clin Oncol, Dept Med Genet & Fundamental Med, Ufa 450008, Russia

[3] Bashkir State Med Univ, Dept Pathol Physiol, Ufa 450008, Russia

[4] Bashkir State Med Univ, Inst Urol & Clin Oncol, Dept Urol, Ufa 450008, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 01期

关键词：

lung cancer; non-coding RNA; miRNA; lncRNA; circRNA; EPITHELIAL-MESENCHYMAL TRANSITION; DOWN-REGULATION CONTRIBUTES; TYROSINE KINASE INHIBITORS; CIRCULAR RNA; MULTIDRUG-RESISTANCE; CELL-PROLIFERATION; UP-REGULATION; PROMOTES CHEMORESISTANCE; SUPPRESSES TUMORIGENESIS; ACQUIRED-RESISTANCE;

D O I：

10.3390/ijms25010560

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For several decades, most lung cancer investigations have focused on the search for mutations in candidate genes; however, in the last decade, due to the fact that most of the human genome is occupied by sequences that do not code for proteins, much attention has been paid to non-coding RNAs (ncRNAs) that perform regulatory functions. In this review, we principally focused on recent studies of the function, regulatory mechanisms, and therapeutic potential of ncRNAs including microRNA (miRNA), long ncRNA (lncRNA), and circular RNA (circRNA) in different types of lung cancer.

引用

页数：34

共 216 条

[1] The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans [J].

Agarwal, Shiuli ;

Vierbuchen, Tim ;

Ghosh, Sreya ;

Chan, Jennie ;

Jiang, Zhaozhao ;

Kandasamy, Richard K. ;

Ricci, Emiliano ;

Fitzgerald, Katherine A. .

NATURE COMMUNICATIONS, 2020, 11 (01)

[2] Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494 [J].

Bai, Yifeng ;

Sun, Yanqin ;

Peng, Juan ;

Liao, Hongzhan ;

Gao, Hongyi ;

Guo, Ying ;

Guo, Linlang .

ONCOTARGET, 2014, 5 (17) :7760-7775

[3] Metazoan MicroRNAs [J].

Bartel, David P. .

CELL, 2018, 173 (01) :20-51

[4] HOX genes and their role in the development of human cancers [J].

Bhatlekar, Seema ;

Fields, Jeremy Z. ;

Boman, Bruce M. .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2014, 92 (08) :811-823

[5] A MicroRNA Signature Predicts Survival in Early Stage Small-Cell Lung Cancer Treated with Surgery and Adjuvant Chemotherapy [J].

Bi, Nan ;

Cao, Jianzhong ;

Song, Yongmei ;

Shen, Jie ;

Liu, Wenyang ;

Fan, Jing ;

He, Jie ;

Shi, Yuankai ;

Zhang, Xun ;

Lu, Ning ;

Zhan, Qimin ;

Wang, Luhua .

PLOS ONE, 2014, 9 (03)

[6] Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer [J].

Borghaei, H. ;

Paz-Ares, L. ;

Horn, L. ;

Spigel, D. R. ;

Steins, M. ;

Ready, N. E. ;

Chow, L. Q. ;

Vokes, E. E. ;

Felip, E. ;

Holgado, E. ;

Barlesi, F. ;

Kohlhaeufl, M. ;

Arrieta, O. ;

Burgio, M. A. ;

Fayette, J. ;

Lena, H. ;

Poddubskaya, E. ;

Gerber, D. E. ;

Gettinger, S. N. ;

Rudin, C. M. ;

Rizvi, N. ;

Crino, L. ;

Blumenschein, G. R. ;

Antonia, S. J. ;

Dorange, C. ;

Harbison, C. T. ;

Finckenstein, F. Graf ;

Brahmer, J. R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (17) :1627-1639

[7] Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers [J].

Cai, Ying ;

Zhu, Chunlan ;

Wang, Yanfei ;

Jiang, Yiqian ;

Zhu, Zhongxin .

FRONTIERS IN GENETICS, 2022, 13

[8] Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas [J].

Calin, George A. ;

Liu, Chang-Gong ;

Ferracin, Manuela ;

Hyslop, Terry ;

Spizzo, Riccardo ;

Sevignani, Cinzia ;

Fabbri, Muller ;

Cimmino, Amelia ;

Lee, Eun Joo ;

Wojcik, Sylwia E. ;

Shimizu, Masayoshi ;

Tili, Esmerina ;

Rossi, Simona ;

Taccioli, Cristian ;

Pichiorri, Flavia ;

Liu, Xiuping ;

Zupo, Simona ;

Herlea, Vlad ;

Gramantieri, Laura ;

Lanza, Giovanni ;

Alder, Hansjuerg ;

Rassenti, Laura ;

Volinia, Stefano ;

Schmittgen, Thomas D. ;

Kipps, Thomas J. ;

Negrini, Massimo ;

Croce, Carlo M. .

CANCER CELL, 2007, 12 (03) :215-229

[9] DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer [J].

Cao, Jianzhong ;

Song, Yongmei ;

Bi, Nan ;

Shen, Jie ;

Liu, Wenyang ;

Fan, Jing ;

Sun, Guogui ;

Tong, Tong ;

He, Jie ;

Shi, Yuankai ;

Zhang, Xun ;

Lu, Ning ;

He, Yinghua ;

Zhang, Hongyu ;

Ma, Kelong ;

Luo, Xiaoying ;

Lv, Lei ;

Deng, Hui ;

Cheng, Jing ;

Zhu, Jingde ;

Wang, Luhua ;

Zhan, Qimin .

CANCER RESEARCH, 2013, 73 (11) :3326-3335

[10] Repression of E-cadherin by the polycomb group protein EZH2 in cancer [J].

Cao, Q. ;

Yu, J. ;

Dhanasekaran, S. M. ;

Kim, J. H. ;

Mani, R-S ;

Tomlins, S. A. ;

Mehra, R. ;

Laxman, B. ;

Cao, X. ;

Yu, J. ;

Kleer, C. G. ;

Varambally, S. ;

Chinnaiyan, A. M. .

ONCOGENE, 2008, 27 (58) :7274-7284

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