Effect of Hypoglycemic Drugs on Kisspeptin Expression in the Hypothalamic Arcuate Nucleus of PCOS Rats

被引：1

作者：

Zheng, Pingping ^{[1
]}

Lu, Yating ^{[2
]}

Tang, You ^{[1
]}

Xu, Fudong ^{[3
]}

Wang, Lin ^{[2
]}

Qian, Rui ^{[4
]}

Hui, Cancan ^{[5
]}

Xu, Qian ^{[2
]}

He, Jianle ^{[1
]}

Deng, Datong ^{[2
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Gen Practice Dept, Hefei, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Endocrinol Dept, Hefei, Peoples R China

[3] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Shoudu Med Univ,Pathol Dept, Beijing, Peoples R China

[4] Anhui Med Univ, Affiliated Hosp 1, Neurol Dept, Hefei, Peoples R China

[5] Anhui Med Univ, Affiliated Hosp 1, Geriatr Endocrinol Dept, Hefei, Peoples R China

来源：

DIABETES METABOLIC SYNDROME AND OBESITY | 2023年 / 16卷

关键词：

polycystic ovary syndrome; PCOS; kisspeptin; metformin; pioglitazone; acarbose; POLYCYSTIC-OVARY-SYNDROME; MESSENGER-RNA; INSULIN; MODEL; ACARBOSE;

D O I：

10.2147/DMSO.S421911

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: To investigate the change in hypothalamic kisspeptin-1 (Kiss1) expression during the development of polycystic ovary syndrome (PCOS) and hypoglycemic drug intervention.Methods: Letrozole lavage was used to construct a polycystic ovary rat model. After successful modeling, we treated PCOS rats with metformin, pioglitazone, and acarbose, and we then observed changes in weight, estrus, glucose tolerance, insulin resistance, sex hormones, and hypothalamic kiss1 expression.Results: PCOS rats exhibited increased body weight, abnormal estrous cycle, impaired glucose tolerance, insulin resistance, increased testosterone level, increased luteinizing hormone level, and increased Kiss1 expression in the hypothalamus. However, intervention with metformin, pioglitazone, and acarbose improved the reproductive and metabolic disorders as well as reduced hypothalamic Kiss1 expression.Conclusion: The expression of hypothalamic Kiss1 may play an important role in the pathogenesis of PCOS. Metformin, pioglitazone, and acarbose may reduce the expression of hypothalamic Kiss1 by improving insulin resistance, thereby improving reproductive and metabolic disorders in PCOS rats.

引用

页码：2717 / 2732

页数：16

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