Antiviral Susceptibility of Highly Pathogenic Avian Influenza A(H5N1) Viruses Circulating Globally in 2022-2023

被引：9
作者：
Andreev, Konstantin [1 ]
Jones, Jeremy C. [1 ]
Seiler, Patrick [1 ]
Kandeil, Ahmed [1 ]
Turner, Jasmine C. M. [1 ]
Barman, Subrata [1 ]
Rubrum, Adam M. [1 ]
Webby, Richard J. [1 ]
Govorkova, Elena A. [1 ,2 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Host Microbe Interact, Memphis, TN USA
[2] St Jude Childrens Res Hosp, Dept Host Microbe Interact, 262 Danny Thomas Pl, Memphis, TN 38105 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2023年 / 229卷 / 06期
基金：
美国国家卫生研究院;
关键词：
resistance; avian influenza; baloxavir; neuraminidase inhibitors; NEURAMINIDASE INHIBITORS; REDUCED SENSITIVITY; H5N1;
D O I：
10.1093/infdis/jiad418
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The antiviral susceptibility of currently circulating (2022-2023) highly pathogenic avian influenza (HPAI) A(H5N1) viruses was assessed by genotypic and phenotypic approaches. The frequency was low for neuraminidase (NA) and polymerase acidic (PA) substitutions associated with reduced inhibition by NA inhibitors (21/2698, 0.78%) or the PA inhibitor baloxavir (14/2600, 0.54%). Phenotypic testing of 22 clade 2.3.2.1a and 2.3.4.4b viruses revealed broad susceptibility to NA inhibitors and baloxavir for a conclusion that most contemporary HPAI A(H5N1) viruses retain susceptibility to antiviral drugs. Novel NA-K432E and NA-T438I substitutions (N2 numbering) were identified at elevated frequencies (104/2698, 3.85%) and caused reduced zanamivir and peramivir inhibition.
引用
收藏
页码：1830 / 1835
页数：6
相关论文
共 15 条
  • [1] Mechanism of 150-cavity formation in influenza neuraminidase
    Amaro, Rommie E.
    Swift, Robert V.
    Votapka, Lane
    Li, Wilfred W.
    Walker, Ross C.
    Bush, Robin M.
    [J]. NATURE COMMUNICATIONS, 2011, 2
  • [2] Profiling and Characterization of Influenza Virus N1 Strains Potentially Resistant to Multiple Neuraminidase Inhibitors
    Baek, Yun Hee
    Song, Min-Suk
    Lee, Eun-Young
    Kim, Young-Il
    Kim, Eun-Ha
    Park, Su-Jin
    Park, Kuk Jin
    Kwon, Hyeok-Il
    Pascua, Philippe Noriel Q.
    Lim, Gyo-Jin
    Kim, Semi
    Yoon, Sun-Woo
    Kim, Myung Hee
    Webby, Richard J.
    Choi, Young-Ki
    [J]. JOURNAL OF VIROLOGY, 2015, 89 (01) : 287 - 299
  • [3] Emergence of H5N1 avian influenza viruses with reduced sensitivity to neuraminidase inhibitors and novel reassortants in Lao People's Democratic Republic
    Boltz, David A.
    Douangngeun, Bounlom
    Phommachanh, Phouvong
    Sinthasak, Settha
    Mondry, Ricarda
    Obert, Caroline
    Seiler, Patrick
    Keating, Rachael
    Suzuki, Yasuo
    Hiramatsu, Hiroaki
    Govorkova, Elena A.
    Webster, Robert G.
    [J]. JOURNAL OF GENERAL VIROLOGY, 2010, 91 : 949 - 959
  • [4] Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes
    Choi, Won-Suk
    Jeong, Ju Hwan
    Kwon, Jin Jung
    Ahn, Su Jeong
    Lloren, Khristine Kaith S.
    Kwon, Hyeok-Il
    Chae, Hee Bok
    Hwang, Jungwon
    Kim, Myung Hee
    Kim, Chul-Joong
    Webby, Richard J.
    Govorkova, Elena A.
    Choi, Young Ki
    Baek, Yun Hee
    Song, Min-Suk
    [J]. JOURNAL OF VIROLOGY, 2018, 92 (01)
  • [5] Highly Pathogenic Avian Influenza A(H5N1) Viruses at the Animal-Human Interface in Vietnam, 2003-2010
    Creanga, Adrian
    Nguyen Le Khanh Hang
    Vuong Duc Cuong
    Nguyen, Ha T.
    Hoang Vu Mai Phuong
    Le Thi Thanh
    Nguyen Co Thach
    Pham Thi Hien
    Nguyen Tung
    Jang, Yunho
    Balish, Amanda
    Nguyen Hoang Dang
    Mai Thuy Duong
    Ngo Thu Huong
    Do Ngoc Hoa
    Nguyen Dang Tho
    Klimov, Alexander
    Kapella, Bryan K.
    Gubareva, Larisa
    Kile, James C.
    Nguyen Tran Hien
    Le Quynh Mai
    Davis, C. Todd
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2017, 216 : S529 - S538
  • [6] Occurrence and fate of oseltamivir carboxylate (Tamiflu) and amantadine in sewage treatment plants
    Ghosh, Gopal Chandra
    Nakada, Norihide
    Yamashita, Naoyuki
    Tanaka, Hiroaki
    [J]. CHEMOSPHERE, 2010, 81 (01) : 13 - 17
  • [7] Influenza antivirals and their role in pandemic preparedness
    Jones, Jeremy C.
    Yen, Hui-Ling
    Adams, Peter
    Armstrong, Kimberly
    Govorkova, Elena A.
    [J]. ANTIVIRAL RESEARCH, 2023, 210
  • [8] Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America
    Kandeil, Ahmed
    Patton, Christopher
    Jones, Jeremy C.
    Jeevan, Trushar
    Harrington, Walter N.
    Trifkovic, Sanja
    Seiler, Jon P.
    Fabrizio, Thomas
    Woodard, Karlie
    Turner, Jasmine C.
    Crumpton, Jeri-Carol
    Miller, Lance
    Rubrum, Adam
    DeBeauchamp, Jennifer
    Russell, Charles J.
    Govorkova, Elena A.
    Vogel, Peter
    Kim-Torchetti, Mia
    Berhane, Yohannes
    Stallknecht, David
    Poulson, Rebecca
    Kercher, Lisa
    Webby, Richard J.
    [J]. NATURE COMMUNICATIONS, 2023, 14 (01)
  • [9] An I436N substitution confers resistance of influenza A(H1N1) pdm09 viruses to multiple neuraminidase inhibitors without affecting viral fitness
    Kwon, Jin Jung
    Choi, Won-Suk
    Jeong, Ju Hwan
    Kim, Eun-Ha
    Lee, Ok-Jun
    Yoon, Sun-Woo
    Hwang, Jungwon
    Webby, Richard J.
    Govorkova, Elena A.
    Choi, Young Ki
    Baek, Yun Hee
    Song, Min-Suk
    [J]. JOURNAL OF GENERAL VIROLOGY, 2018, 99 (03) : 292 - 302
  • [10] Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-Glade antibody responses than homologous prime-boost
    Levine, Min Z.
    Holiday, Crystal
    Jefferson, Stacie
    Gross, F. Liaini
    Liu, Feng
    Li, Sheng
    FrieI, Damien
    Boutet, Philippe
    Innis, Bruce L.
    Mallett, Corey P.
    Tumpey, Terrence M.
    Stevens, James
    Katz, Jacqueline M.
    [J]. NPJ VACCINES, 2019, 4 (1)
12