Pancreatitis and Hyperlipasemia in the Setting of Immune Checkpoint Inhibitor Therapy

被引：4

作者：

Townsend, Matthew J. ^{[1
]}

Liu, Mofei ^{[2
]}

Giobbie-Hurder, Anita ^{[2
]}

Sack, Jordan S. ^{[3
,4
]}

Leboeuf, Nicole R. ^{[4
,5
]}

Hodi, Stephen ^{[6
]}

McNabb-Baltar, Julia ^{[3
,4
]}

Grover, Shilpa ^{[3
,4
,7
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC USA

[2] Dana Farber Canc Inst, Dept Data Sci, Div Biostat, Boston, MA USA

[3] Brigham & Womens Hosp, Div Gastroenterol Hepatol & Endoscopy, Boston, MA USA

[4] Harvard Med Sch, Boston, MA USA

[5] Dana Farber Brigham & Womens Canc Ctr, Ctr Cutaneous Oncol, Dept Dermatol, Boston, MA USA

[6] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA USA

[7] Brigham & Womens Hosp, Div Gastroenterol Hepatol & Endoscopy, 75 Francis St, Boston, MA 02115 USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2023年 / 21卷 / 08期

关键词：

ADVERSE EVENTS; EFFICACY; ASSOCIATION;

D O I：

10.6004/jnccn.2023.7034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Immune checkpoint inhibitor-induced pancreatic injury (ICI-PI) ranges from asymptomatic hyperlipasemia to symptomatic acute pancreatitis (AP). The proportion of pancreatic injury while receiving ICIs that is attributable to therapy remains unclear. We evaluated the etiology of hyperlipasemia in patients receiving ICIs, and the clinical characteristics, management, and outcomes of ICI-PI. Patients and Methods: We assessed 6,450 consecutive adult patients with cancer who received ICI doses between 2011 and 2019, 364 of whom had at least 1 instance of elevated serum lipase after ICI initiation and were included in our trial. Primary outcomes were the development of ICI-PI and ICI-induced acute pancreatitis (ICI-AP). Results: Pancreatic injury was attributable to ICI use in 105 individuals (29% of those with sented asymptomatically with hyperlipasemia and pancreatic inflamdoi: 10.6004/jnccn.2023.7034

引用

页码：831 / +

页数：14

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