Prognostic significance of eighth edition TNM stage criteria in combined small-cell lung cancer

被引：1
作者：
Zhao, Ziran [1 ]
Gao, Yibo [1 ]
Tan, Fengwei [1 ]
Xue, Qi [1 ]
Gao, Shugeng [1 ]
He, Jie [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Thorac Surg Dept,Natl Clin Res Ctr Canc, Beijing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
基金：
中国国家自然科学基金;
关键词：
combined small cell lung cancer (c-SCLC); 8th TNM stage criteria; prognostic significance; SEER database; surgery; CLASSIFICATION; REVISION; VALIDATION; PROPOSALS;
D O I：
10.3389/fonc.2023.1018288
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
ObjectivesThis study aimed to evaluate the prognostic significance of the eighth edition TNM stage criteria in patients with combined small-cell lung cancer (C-SCLC) on a population level. MethodsUsing the Surveillance, Epidemiology, and End Results (SEER) database, patients diagnosed with C-SCLC (histology code 8245) between the years 2004 and 2015 were identified. We performed a Kaplan-Meier analysis and used the multivariable cox regression proportional hazards model to obtain prognostic overall survival estimates for each group of patients. ResultsA total of 477 patients diagnosed with C-SCLC were identified. The T, N, M, TNM, and combined TNM stage status of the eighth edition were all significant prognostic factors for patients' overall survivals, with the best discrimination identified in the combined stages. Surgery was also found to be a prognostic factor (HR =1.95, 95%CI =1.49-2.56, p<0.01) for patients with C-SCLC. ConclusionsThe combined eighth edition of the TNM staging criteria shows reliable prognostic significance in patients with C-SCLC. Moreover, surgery might be significant for improving the patients' prognosis.
引用
收藏
页数：7
相关论文
共 50 条
[21]   Comparison of seventh TNM and eighth TNM staging system in stage III non-small cell lung cancer patients treated with concurrent chemoradiotherapy [J].
Yilmaz, Ufuk ;
Ozdemir, Ozer ;
Yilmaz, Ulku .
CURRENT PROBLEMS IN CANCER, 2019, 43 (01) :33-42
[22]   The IASLC Lung Cancer Staging Project Proposals Regarding the Relevance of TNM in the Pathologic Staging of Small Cell Lung Cancer in the Forthcoming (Seventh) Edition of the TNM Classification for Lung Cancer [J].
Vallieres, Eric ;
Shepherd, Frances A. ;
Crowley, John ;
Van Houtte, Paul ;
Postmus, Pieter E. ;
Carney, Desmond ;
Chansky, Kari ;
Shaikh, Zeba ;
Goldstraw, Peter .
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) :1049-1059
[23]   Neutrophil-lymphocyte ratio is prognostic in early stage resected small-cell lung cancer [J].
Lohinai, Zoltan ;
Bonanno, Laura ;
Aksarin, Aleksei ;
Pavan, Alberto ;
Megyesfalvi, Zsolt ;
Santa, Balazs ;
Hollosi, Virag ;
Hegedus, Balazs ;
Moldvay, Judit ;
Conte, PierFranco ;
Ter-Ovanesov, Mikhail ;
Bilan, Evgeniy ;
Dome, Balazs ;
Weiss, Glen J. .
PEERJ, 2019, 7
[24]   The IASLC Lung Cancer Staging Project Proposals for the Revision of the M Descriptors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer [J].
Eberhardt, Wilfried E. E. ;
Mitchell, Alan ;
Crowley, John ;
Kondo, Haruhiko ;
Kim, Young Tae ;
Turrisi, Andrew, III ;
Goldstraw, Peter ;
Rami-Porta, Ramon .
JOURNAL OF THORACIC ONCOLOGY, 2015, 10 (11) :1515-1522
[25]   Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor [J].
Hiltermann, T. J. N. ;
Pore, M. M. ;
van den Berg, A. ;
Timens, W. ;
Boezen, H. M. ;
Liesker, J. J. W. ;
Schouwink, J. H. ;
Wijnands, W. J. A. ;
Kerner, G. S. M. A. ;
Kruyt, F. A. E. ;
Tissing, H. ;
Tibbe, A. G. J. ;
Terstappen, L. W. M. M. ;
Groen, H. J. M. .
ANNALS OF ONCOLOGY, 2012, 23 (11) :2937-2942
[26]   The International Association for the Study of Lung Cancer Staging Project Prognostic Factors and Pathologic TNM Stage in Surgically Managed Non-small Cell Lung Cancer [J].
Chansky, Kari ;
Sculier, Jean-Paul ;
Crowley, John J. ;
Giroux, Dori ;
Van Meerbeeck, Jan ;
Goldstraw, Peter .
JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (07) :792-801
[27]   Prognostic Relevance of Negative Lymph Node Count in Resected Stage I-IIIa Small-cell Lung Cancer [J].
Yang, Hao ;
Li, Dongmei ;
Liu, Tong .
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2023, 46 (07) :306-313
[28]   COMBINED MODALITY THERAPY FOR SMALL-CELL LUNG-CANCER [J].
SAIJO, N ;
KUNITO ;
JOHNSON, DM ;
BUNN, PA .
ONCOLOGY, 1992, 49 :2-10
[29]   A Nomogram for Predicting Cancer-Specific Survival of TNM 8th Edition Stage I Non-small-cell Lung Cancer [J].
Zeng, Yuan ;
Mayne, Nicholas ;
Yang, Chi-Fu Jeffrey ;
D'Amico, Thomas A. ;
Ng, Calvin S. H. ;
Liu, Chia-chuan ;
Petersen, Rene Horsleben ;
Rocco, Gaetano ;
Brunelli, Alessandro ;
Liu, Jun ;
Liu, Yang ;
Huang, Weizhe ;
He, Jiaxi ;
Wang, Wei ;
Jiang, Long ;
Cui, Fei ;
Wang, Wenjun ;
Liang, Wenhua ;
He, Jianxing .
ANNALS OF SURGICAL ONCOLOGY, 2019, 26 (07) :2053-2062
[30]   Combined small-cell lung carcinoma [J].
Qin, Jing ;
Lu, Hongyang .
ONCOTARGETS AND THERAPY, 2018, 11 :3505-3511
12345