Retinal Thinning in Adults with Autism Spectrum Disorder

被引：11

作者：

Friedel, Evelyn B. N. ^{[1
,2
,3
]}

van Elst, Ludger Tebartz ^{[1
]}

Schaefer, Mirjam ^{[1
]}

Maier, Simon ^{[1
]}

Runge, Kimon ^{[1
]}

Kuechlin, Sebastian ^{[2
]}

Reich, Michael ^{[2
]}

Lagreze, Wolf A. ^{[2
]}

Kornmeier, Juergen ^{[1
,4
]}

Ebert, Dieter ^{[1
]}

Endres, Dominique ^{[1
]}

Domschke, Katharina ^{[1
,5
]}

Nickel, Kathrin ^{[1
]}

机构：

[1] Univ Freiburg, Med Ctr, Fac Med, Dept Psychiat & Psychotherapy, Freiburg, Germany

[2] Univ Freiburg, Fac Med, Eye Ctr, Freiburg, Germany

[3] Univ Freiburg, Fac Biol, Freiburg, Germany

[4] Inst Frontier Areas Psychol & Mental Hlth, Freiburg, Germany

[5] Univ Freiburg, Fac Med, Ctr Basics Neuromodulat, Freiburg, Germany

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2024年 / 54卷 / 03期

关键词：

Autism spectrum disorder; ASD; Optical coherence tomography; OCT; Retina; HIGH-FUNCTIONING AUTISM; OPTICAL COHERENCE TOMOGRAPHY; RECOMMENDATIONS; ASSOCIATION; THICKNESS; QUOTIENT;

D O I：

10.1007/s10803-022-05882-8

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT. Both macular and ONL thickness showed significant inverse associations with the severity of autistic symptoms measured with the Social Responsiveness Scale 2 (SRS-2). Longitudinal studies across different age groups are required to clarify whether retinal changes may represent a possible trait marker.

引用

页码：1143 / 1156

页数：14

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