Innovating Evaluation and Treatment of Intrapartum Fevers: Where Do We Go from Here?

被引：0

作者：

Wilkie, Gianna L. ^{[1
,2
,3
]}

James, Kaitlyn ^{[2
]}

Ona, Samsiya ^{[1
,2
]}

Easter, Sarah Rae ^{[1
]}

Chou, Joseph ^{[4
]}

Roberts, Drucilla ^{[5
]}

Sahin, Zehra Ordulu ^{[5
]}

Tuomala, Ruth ^{[1
]}

Diouf, Khady ^{[1
]}

Riley, Laura ^{[2
,6
]}

Prabhu, Malavika ^{[2
,6
]}

机构：

[1] Harvard Med Sch, Dept Obstet & Gynecol, Brigham & Womens Hosp, Boston, MA USA

[2] Harvard Med Sch, Dept Obstet & Gynecol, Massachusetts Gen Hosp, Boston, MA USA

[3] Univ Massachusetts, Dept Obstet & Gynecol, Univ Massachusetts Med Sch, Mem Med Ctr, Worcester, MA USA

[4] Harvard Med Sch, Dept Pediat, Massachusetts Gen Hosp, Boston, MA USA

[5] Harvard Med Sch, Dept Pathol, Massachusetts Gen Hosp, Boston, MA USA

[6] Weill Cornell Med, Dept Obstet & Gynecol, New York, NY USA

来源：

AMERICAN JOURNAL OF PERINATOLOGY | 2023年 / 40卷 / 03期

关键词：

intrapartum fever; early onset sepsis; intraamniotic infection; POLYMERASE-CHAIN-REACTION; EARLY-ONSET SEPSIS; INFLAMMATORY RESPONSE; ANTIBIOTIC USE; MANAGEMENT; RISK; CHORIOAMNIONITIS; INTERLEUKIN-6; BACTEREMIA; NEWBORNS;

D O I：

10.1055/s-0041-1727279

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

As intrapartum fevers are not always infectious in origin, determining whether antibiotics are indicated is challenging. We previously sought to create a point-of-care calculator using clinical data available at the time of an intrapartum fever to identify the subset of women who require antibiotic treatment to avoid maternal and neonatal morbidity. Despite the use of a comprehensive dataset from our institutions, we were unable to propose a valid and highly predictive model. In this commentary, we discuss why our model failed, as well as future research directions to identify and treat true intraamniotic infection. Developing a risk-stratification model is paramount to minimizing maternal and neonatal exposure to unnecessary antibiotics while allowing for early identification of women and babies at risk for infectious morbidity.

引用

页码：250 / 254

页数：5

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