Dysregulation of miRNA expression in patients with chronic myelogenous leukemia at diagnosis: a systematic review

被引：3

作者：

Parsa-kondelaji, Mohammad ^{[1
]}

Musavi, Maryam ^{[2
]}

Barzegar, Faezeh ^{[1
]}

Abbasian, Neda ^{[3
]}

Rostami, Mehrdad ^{[1
]}

R Seyedtaghia, Mohammad ^{[4
]}

S Hashemi, Seyyed ^{[4
]}

Modi, Mahdiyeh ^{[2
,5
]}

Nikfar, Banafsheh ^{[6
]}

A Momtazi-Borojeni, Amir ^{[2
,5
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Hematol & Blood Banking, Mashhad, Iran

[2] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran

[3] Mashhad Univ Med Sci, Emam Reza Hosp, Hematol & Blood Banking Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Sch Med, Dept Med Genet & Mol Med, Mashhad, Iran

[5] Neyshabur Univ Med Sci, Fac Med, Dept Med Biotechnol, Neyshabur, Iran

[6] Iran Univ Med Sci, Pars Hosp, Pars Adv & Minimally Invas Med Manners Res Ctr, Tehran, Iran

来源：

BIOMARKERS IN MEDICINE | 2023年 / 17卷 / 24期

关键词：

chronic myeloid leukemia; miRNAs; systematic review; CHRONIC MYELOID-LEUKEMIA; INHIBITS CELL-PROLIFERATION; BONE-MARROW NICHE; STEM-CELLS; DOWN-REGULATION; IMATINIB; MICRORNAS; APOPTOSIS; SURVIVAL; ANGIOGENESIS;

D O I：

10.2217/bmm-2023-0575

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: The present systematic review aimed to explore miRNAs as a potential biomarker for early diagnosis of chronic myeloid leukemia (CML). Materials & methods: A systematic search was conducted in three electronic databases, including Web of Science, Scopus, and PubMed, to obtain relevant articles investigating the alteration of miRNA expression in patients with CML. Results: The authors found miRNAs whose expression changes are effective in the induction of CML disease. Among them, miR-21 and miR-155 were identified as the most common miRNAs with increased expression and miR-150 and miR-146 as the most common miRNAs with decreased expression. Conclusion: miRNAs can be used as an indicator for the early detection and treatment of CML phase.

引用

页码：1021 / 1029

页数：9

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