High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis - TREATgermany registry analysis

Background: Eczema herpeticum (EH) is a disseminated skin infection causedby herpes simplex virus in atopic dermatitis (AD) patients. The frequency of EH and the clinical features of EH patients have not yet been investigated in a larger cohort. Methods: We sought to investigate the TREATgermany cohort, a multicenter, non-interventional clinical registry of moderately to severely affected AD patients in Germany. Baseline characteristics of patients included between December 2017 and April 2021 were compared between patients without, single, and multiple EH. Results: Of the 893 patients, 195 (21.8%) had at least one EH. Of the 195 patientswith EH, 107 had multiple EH (54.9%), representing 12.0% of the total study pop-ulation. While there were no differences in demographic characteristics, previoustreatment, and disease scores at enrollment (itch, IGA, oSCORAD, EASI), patientswith EH had more frequent atopic comorbidities and sensitizations to house dustmite, food, and mold. Discussion: TREATgermany registry data suggest a high prevalence and recur-rence rate of EH, while there appears to be no specific clinical phenotype, besidesan increase in allergies, to identify EH patients in the daily routine.