Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review

被引：7
作者：
Tang, Jun [1 ]
Yousaf, Muhammad [1 ]
Wu, Ya-Ping [1 ]
Li, Qin-qin [1 ]
Xu, Yi-Qian [1 ]
Liu, Dong-Mei [1 ,2 ]
机构：
[1] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China
[2] South China Univ Technol, Sch Food Sci & Engn, 381 Wushan Rd, Guangzhou 510640, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 254卷
关键词：
Polysaccharide; Alzheimer's disease; Mechanisms; Structure-activity relationships; LONICERA JAPONICA THUNB; SIMPLEX-VIRUS TYPE-1; AMYLOID-BETA; COGNITIVE IMPAIRMENT; INDUCED NEUROINFLAMMATION; A-BETA(42) AGGREGATION; OXIDATIVE STRESS; LYCIUM-BARBARUM; KAPPA-B; PURIFICATION;
D O I：
10.1016/j.ijbiomac.2023.127553
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is a complex neurodegenerative disease. Despite several decades of research, the development of effective treatments and responses for Alzheimer's disease remains elusive. The utilization of polysaccharides for Alzheimer's disease became more popular due to their beneficial characteristics, notably their multi-target activity and low toxicity. This review mainly focuses on the researches of recent 5 years in the regulation of AD by naturally derived polysaccharides, systematically lists the possible intervention pathways of polysaccharides from different mechanisms, and explores the structure-activity relationship between polysaccharide structural activities, so as to provide references for the intervention and treatment of AD by polysaccharides.
引用
收藏
页数：15
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