Associations of spleen volume with markers of blood count and lipid profile in a large population-based study

被引：2

作者：

Naeem, Muhammad ^{[1
,8
]}

Ittermann, Till ^{[1
]}

Markus, Marcello Ricardo Paulista ^{[2
]}

Mousa, Mohammed Farah Mahmoud ^{[1
]}

von Heder, Laura ^{[1
]}

Buelow, Robin ^{[3
]}

Doerr, Marcus ^{[2
]}

Nauck, Matthias ^{[4
]}

Agdassi, Ali ^{[5
]}

Heidel, Florian H. ^{[6
,7
]}

Voelzke, Henry ^{[1
]}

机构：

[1] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

[2] Univ Med Greifswald, Dept Internal Med Cardiol B, Intens Care Pulm Med & Infect Dis, Greifswald, Germany

[3] Univ Med Greifswald, Inst Radiol & Neuradiol, Greifswald, Germany

[4] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany

[5] Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany

[6] Univ Med Greifswald, Dept Internal Med C, Greifswald, Germany

[7] Hannover Med Sch MHH, Hematol Hemostasis Oncol & Stem Cell Transplantat, Hannover, Germany

[8] Univ Malakand, Dept Zool, Totakan 18800, Pakistan

来源：

UPSALA JOURNAL OF MEDICAL SCIENCES | 2023年 / 128卷 / 01期

关键词：

spleen volume; MRI; blood count; lipid profile; CLONAL HEMATOPOIESIS; SPLENECTOMY; METABOLISM; SIZE; RISK;

D O I：

10.48101/ujms.v128.9785

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The aim of our study was to investigate associations of spleen volume with blood count markers and lipid profile in the general population. Materials & methods: Cross-sectional data from 1,106 individuals aged 30-90 years from the population-based Study of Health in Pomerania (SHIP-START-2) were analyzed. Blood count markers included red blood cell (RBC) counts, hemoglobin, platelet count, and white blood cell (WBC) counts. Lipid profile included total-cholesterol, high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) as well as triglycerides. Linear regression models adjusted for age, sex, body height, and weight were used to associate standardized spleen volume with blood counts and lipid profile markers. Results: Spleen volume was positively associated with RBC (beta = 0.05; 95% confidence interval [CI] = 0.03 to 0.08) and hemoglobin (beta = 0.05; 95% CI = 0.01 to 0.09) but inversely with platelet count (beta = -16.3; 95% CI = -20.5 to -12.1) and WBC (beta = -0.25; 95% CI = -0.37 to -0.14). Furthermore, spleen volume showed inverse associations with total cholesterol (beta = -0.17; 95% CI = -0.24 to -0.09), HDL-C (beta = -0.08; 95% CI = -0.10 to -0.05), and LDL-C (beta = -0.12; 95% CI = -0.17 to -0.06). There was no significant association of spleen volume with triglycerides. Conclusion: Our study showed that the spleen volume is associated with markers of the blood count and lipid profile in the general population.

引用

页数：6

共 25 条

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