Genome, Metabolism, or Immunity: Which Is the Primary Decider of Pancreatic Cancer Fate through Non-Apoptotic Cell Death?

被引：3
作者：
Barar, Erfaneh [1 ]
Shi, Jiaqi [2 ,3 ]
机构：
[1] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Inst, Liver & Pancreatobiliary Dis Res Ctr, Tehran 1416753955, Iran
[2] Univ Michigan, Rogel Canc Ctr, Ctr RNA Biomed, Dept Pathol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Rogel Canc Ctr, Ctr RNA Biomed, Clin Labs, Ann Arbor, MI 48109 USA
来源：
BIOMEDICINES | 2023年 / 11卷 / 10期
基金：
美国国家卫生研究院;
关键词：
pancreatic ductal adenocarcinoma; apoptosis; ferroptosis; necroptosis; pyroptosis; NF-KAPPA-B; DUCTAL ADENOCARCINOMA; AURORA KINASE; NECROPTOSIS; FERROPTOSIS; PYROPTOSIS; EXPRESSION; PROGNOSIS; GENES; MICROENVIRONMENT;
D O I：
10.3390/biomedicines11102792
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is a solid tumor characterized by poor prognosis and resistance to treatment. Resistance to apoptosis, a cell death process, and anti-apoptotic mechanisms, are some of the hallmarks of cancer. Exploring non-apoptotic cell death mechanisms provides an opportunity to overcome apoptosis resistance in PDAC. Several recent studies evaluated ferroptosis, necroptosis, and pyroptosis as the non-apoptotic cell death processes in PDAC that play a crucial role in the prognosis and treatment of this disease. Ferroptosis, necroptosis, and pyroptosis play a crucial role in PDAC development via several signaling pathways, gene expression, and immunity regulation. This review summarizes the current understanding of how ferroptosis, necroptosis, and pyroptosis interact with signaling pathways, the genome, the immune system, the metabolism, and other factors in the prognosis and treatment of PDAC.
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页数：30
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