Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry

被引:9
作者
Akram, Wasim [1 ]
Rihan, Mohd [2 ]
Ahmed, Sakeel [2 ]
Arora, Swamita [3 ]
Ahmad, Sameer [4 ]
Vashishth, Rahul [5 ]
机构
[1] Jamia Hamdard, Dept Pharmacol, SPER, New Delhi 110062, India
[2] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Mohali 160062, India
[3] RV Northland Inst Pharm, Dept Pharmacol, Dadri 203207, India
[4] Dept Food Technol Jamia Hamdard, New Delhi 110062, India
[5] Vellore Inst Technol, Sch Biosci & Technol Food Technol, Vellore 632014, India
关键词
marine drugs; cardiovascular diseases (CVDs); atherosclerosis; hypertension; myocardial infarction; PLATELET-ACTIVATING-FACTOR; I-CONVERTING-ENZYME; NATURAL-PRODUCTS; OXIDATIVE STRESS; CARDIAC DYSFUNCTION; INHIBITORY PEPTIDES; INDOLE ALKALOIDS; GLOBAL BURDEN; FISH-OIL; ASTAXANTHIN;
D O I
10.3390/md21030193
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Cardiovascular diseases (CVDs) are among the most impactful illnesses globally. Currently, the available therapeutic option has several side effects, including hypotension, bradycardia, arrhythmia, and alteration in different ion concentrations. Recently, bioactive compounds from natural sources, including plants, microorganisms, and marine creatures, have gained a lot of interest. Marine sources serve as reservoirs for new bioactive metabolites with various pharmacological activities. The marine-derived compound such as omega-3 acid ethyl esters, xyloketal B, asperlin, and saringosterol showed promising results in several CVDs. The present review focuses on marine-derived compounds' cardioprotective potential for hypertension, ischemic heart disease, myocardial infarction, and atherosclerosis. In addition to therapeutic alternatives, the current use of marine-derived components, the future trajectory, and restrictions are also reviewed.
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页数:29
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