Optimized BEAC conditioning regimen improves clinical outcomes of autologous hematopoietic stem cell transplantation in non-Hodgkin lymphomas

被引：0

作者：

Zhou, Sha ^{[1
]}

Rao, Jun ^{[1
,2
]}

Ma, Xiangyu ^{[3
]}

Zeng, Yunjing ^{[1
]}

Xiang, Xixi ^{[1
]}

Li, Jiali ^{[1
]}

Liu, Hongyun ^{[1
]}

Lin, Shijia ^{[1
]}

Dong, Song ^{[1
]}

Li, Fu ^{[1
]}

Zhang, Xi ^{[1
,2
]}

Gao, Li ^{[1
]}

机构：

[1] Army Med Univ, Xinqiao Hosp, Med Ctr Hematol, State Key Lab Trauma & Chem Poisoning,Chongqing Ke, Chongqing, Peoples R China

[2] Soochow Univ, Natl Clin Res Ctr Hematol Dis, Affiliated Hosp 1, Suzhou, Peoples R China

[3] Army Med Univ, Dept Epidemiol, Chongqing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2024年 / 120卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Non-Hodgkin lymphoma; Conditioning regimen; Autologous hematopoietic stem cell transplantation; BEAC; MULTICENTER PHASE-II; FOLLOW-UP; CHEMOTHERAPY; SURVIVAL; EFFICACY; THERAPY; CYCLOPHOSPHAMIDE; MUCOSITIS; ETOPOSIDE; SUPPORT;

D O I：

10.1007/s12185-024-03755-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The conditioning regimen is an important part of autologous hematopoietic stem cell transplantation (ASCT). We explored the efficacy and safety of an optimized BEAC (adjusted-dose, intermediate-dose cytarabine and reduced-dose cyclophosphamide, AD-BEAC) conditioning regimen for non-Hodgkin lymphoma (NHL). A total of 141 NHL patients received AD-BEAC or a standard-dose BEAC (SD-BEAC) conditioning regimen from January 2007 to December 2017, and 104 patients were included in the study after 1:1 propensity matching. The 5-year overall survival (OS) and progression free survival (PFS) rates were significantly higher with AD-BEAC than with SD-BEAC (82.7% vs. 67.3%, P = 0.039; 76.9% vs. 57.7%, P = 0.039). Transplant-related mortality (TRM) was 3.8% in both the AD-BEAC and SD-BEAC groups. The AD-BEAC group had lower incidence of oral ulcers and cardiotoxicity than the SD-BEAC group. An optimized BEAC conditioning regimen is an effective conditioning regimen for ASCT in NHL with acceptable toxicity, that is more effective and safer than a standard BEAC conditioning regimen.

引用

页码：96 / 105

页数：10

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