Immune checkpoint blockade improves the activation and function of circulating mucosal-associated invariant T (MAIT) cells in patients with non-small cell lung cancer

被引：5

作者：

Sundstrom, Patrik ^{[1
]}

Dutta, Nikita ^{[1
]}

Rodin, William ^{[1
]}

Hallqvist, Andreas ^{[2
,3
]}

Raghavan, Sukanya ^{[1
,4
]}

Jarbrink, Marianne Quiding ^{[1
]}

机构：

[1] Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Box 435, S-40530 Gothenburg, Sweden

[2] Univ Gothenburg, Inst Clin Sci, Sahlgrenska Acad, Dept Oncol, Gothenburg, Sweden

[3] Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden

[4] Sahlgrens Univ Hosp, Dept Clin Immunol & Transfus Med, Gothenburg, Sweden

来源：

ONCOIMMUNOLOGY | 2024年 / 13卷 / 01期

基金：

芬兰科学院; 瑞典研究理事会;

关键词：

Immune checkpoint blockade; immunotherapy; MAIT cell; non-small cell lung cancer; PD-1; THERAPY;

D O I：

10.1080/2162402X.2024.2312631

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mucosal-associated invariant T (MAIT) cells constitute one of the most numerous unconventional T cell subsets, and are characterized by rapid release of Th1- and Th17-associated cytokines and increased cytotoxic functions following activation. MAIT cells accumulate in tumor tissue but show an exhausted phenotype. Here, we investigated if immune checkpoint blockade (ICB) with antibodies to PD-1 or PD-L1 affects the function of circulating MAIT cells from non-small cell lung cancer patients. ICB increased the proliferation and co-expression of the activation markers HLA-DR and CD38 on MAIT cells in most patients after the first treatment cycle, irrespective of treatment outcome. Furthermore, production of cytokines, especially TNF and IL-2, also increased after treatment, as did MAIT cell polyfunctionality. These results indicate that MAIT cells respond to ICB, and that MAIT cell reinvigoration may contribute to tumor regression in patients undergoing immune checkpoint therapy.

引用

页数：8

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