Inflammation-related prognostic markers in resected hepatocellular carcinoma

被引:6
作者
Giannone, Fabio [1 ,2 ,3 ]
Slovic, Nevena [1 ]
Pessaux, Patrick [1 ,2 ,3 ]
Schuster, Catherine [1 ]
Baumert, Thomas F. [1 ,3 ,4 ,5 ]
Lupberger, Joachim [1 ]
机构
[1] Univ Strasbourg, Inst Rech Malad Virales & Hepat, Inserm, Unite Mixte Rech UMR S1110, Strasbourg, France
[2] Hop Univ Strasbourg, Serv Chirurg Viscerale & Digest, Unite Chirurg Hepatobiliaire & Pancreat, Strasbourg, France
[3] Inst Hosp Univ IHU, Strasbourg, France
[4] Hop Univ Strasbourg, Serv Hepatogastroenterol, Strasbourg, France
[5] Inst Univ France IUF, Paris, France
来源
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词
HCC; biomarkers; genetic signatures; inflammation; patient outcome; LYMPHOCYTE RATIO; GENE-EXPRESSION; CANCER; SURVIVAL; NEUTROPHIL; IMMUNE; SCORE; RISK; RECURRENCE; SIGNATURE;
D O I
10.3389/fonc.2023.1267870
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocellular carcinoma is usually detected late and therapeutic options are unsatisfactory. Despite marked progress in patient care, HCC remains among the deadliest cancers world-wide. While surgical resection remains a key option for early-stage HCC, the 5-year survival rates after surgical resection are limited. One reason for limited outcomes is the lack of reliable prognostic biomarkers to predict HCC recurrence. HCC prognosis has been shown to correlate with different systemic and pathological markers which are associated with patient survival and HCC recurrence. Liver inflammatory processes offer a large variety of systemic and pathological markers which may be exploited to improve the reliability of prognosis and decision making of liver surgeons and hepatologists. The following review aims to dissect the potential tools, targets and prognostic meaning of inflammatory markers in patients with resectable HCC. We analyze changes in circulant cellular populations and assess inflammatory biomarkers as a surrogate of impaired outcomes and provide an overview on predictive gene expression signatures including inflammatory transcriptional patterns, which are representative of poor survival in these patients.
引用
收藏
页数:9
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