Metabonomics and the gut microbiome analysis of the effect of 6-shogaol on improving obesity

被引：23

作者：

Jiao, Wenya ^{[1
]}

Sang, Yaxin ^{[1
]}

Wang, Xianghong ^{[1
]}

Wang, Shuo ^{[2
]}

机构：

[1] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071000, Peoples R China

[2] Nankai Univ, Tianjin Key Lab Food Sci & Hlth, Sch Med, Tianjin 9300071, Peoples R China

来源：

FOOD CHEMISTRY | 2023年 / 404卷

关键词：

6-Shogaol; Anti-obesity; Gut microbiome; Metabolomics; GINGER ZINGIBER-OFFICINALE; SEQUENCES;

D O I：

10.1016/j.foodchem.2022.134734

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study investigated the ability of 6-shogaol to reduce obesity in C57BL/6J mice fed with high-fat diet (HFD). After 12 weeks of 6-shogaol (20, 40, 60 mg/kg/2 days) intervention, obesity related indicators, gut microbiota and metabonomics of mice were analyzed. The obesity degree and blood lipid level of mice treated with 6-shogaol were reduced, and glucose homeostasis was improved, especially in mice treated with low-dose. The intervention of 6-shogaol increased the diversity of gut microbiota and decreased the ratio of Firmicutes and Bacteroides. 6-shogaol also led to changes in metabonomics. There were 5, 4 and 6 different metabolites of 6-shogaol at low, medium and high doses. Among them, Solacauline, PE (22:5 (4Z, 7z, 10z, 13z, 13z, 16z)/14:1 (9z)) and presqualene diphosphate have strong correlation with Akkermansia, Brucella, Odoribacter and Mucispirillum. This study aims to provide a theoretical foundation for clarifying the molecular mechanism of 6-shogaol in improving obesity.

引用

页数：9

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