Research progress in the development of natural-product-based mucosal vaccine adjuvants

被引：15

作者：

Gao, Yingying ^{[1
]}

Guo, Ying ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Clin Lab, Affiliated Banan Hosp, Chongqing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

关键词：

mucosal vaccines; adjuvants; polysaccharides; saponins; natural-product-based; IMMUNE-RESPONSES; DENDRITIC CELLS; DELTA INULIN; ANTIGEN; SAPONINS; CHITOSAN; IMMUNOGENICITY; ANTIBODIES; ADVAX(TM); EFFICACY;

D O I：

10.3389/fimmu.2023.1152855

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal vaccines have great potential and advantages in preventing infection caused by multiple pathogens. In developing mucosal vaccines, the biggest challenge comes from finding safe and effective adjuvants and drug delivery systems. Great progress has been made in the generation of mucosal adjuvants using detoxified bacterial toxin derivatives, pathogen-related molecules, cytokines, and various vaccine delivery systems. However, many problems, relating to the safety and efficacy of mucosal vaccine adjuvants, remain. Certain natural substances can boost the immune response and thus could be used as adjuvants in vaccination. These natural-product-based immune adjuvants have certain advantages over conventional adjuvants, such as low toxicity, high stability, and low cost of production. In this review, we summarize the latest natural-product-based immune adjuvants, and discuss their properties and clinical applications.

引用

页数：8

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