Mass spectrometry-based metabolomics for discovering active ingredients and exploring action mechanism of herbal medicine

被引:13
作者
Guo, Sifan [1 ,2 ,3 ]
Qiu, Shi [1 ,2 ]
Cai, Ying [3 ]
Wang, Zhibo [3 ]
Yang, Qiang [3 ]
Tang, Songqi [1 ,2 ]
Xie, Yiqiang [1 ,2 ]
Zhang, Aihua [1 ,2 ,3 ]
机构
[1] Hainan Med Univ, Sci Expt Ctr, Int Adv Funct Omics Platform, Haikou, Peoples R China
[2] Hainan Med Univ, Hainan Gen Hosp, Coll Chinese Med, Haikou, Peoples R China
[3] Heilongjiang Univ Chinese Med, Grad Sch, Harbin, Peoples R China
来源
FRONTIERS IN CHEMISTRY | 2023年 / 11卷
关键词
Metabolomic; mass spectrometry; herbal medicine; target; biomarker; mechanism; TRADITIONAL CHINESE MEDICINE; PERFORMANCE LIQUID-CHROMATOGRAPHY; COMPATIBILITY RATIONALITY; NETWORK PHARMACOLOGY; ORBITRAP; MS; FUTURE; GENIPOSIDE; HIGHLIGHTS; DIAGNOSIS;
D O I
10.3389/fchem.2023.1142287
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Natural products derived from herbal medicine are a fruitful source of lead compounds because of their structural diversity and potent bioactivities. However, despite the success of active compounds derived from herbal medicine in drug discovery, some approaches cannot effectively elucidate the overall effect and action mechanism due to their multi-component complexity. Fortunately, mass spectrometry-based metabolomics has been recognized as an effective strategy for revealing the effect and discovering active components, detailed molecular mechanisms, and multiple targets of natural products. Rapid identification of lead compounds and isolation of active components from natural products would facilitate new drug development. In this context, mass spectrometry-based metabolomics has established an integrated pharmacology framework for the discovery of bioactivity-correlated constituents, target identification, and the action mechanism of herbal medicine and natural products. High-throughput functional metabolomics techniques could be used to identify natural product structure, biological activity, efficacy mechanisms, and their mode of action on biological processes, assisting bioactive lead discovery, quality control, and accelerating discovery of novel drugs. These techniques are increasingly being developed in the era of big data and use scientific language to clarify the detailed action mechanism of herbal medicine. In this paper, the analytical characteristics and application fields of several commonly used mass spectrometers are introduced, and the application of mass spectrometry in the metabolomics of traditional Chinese medicines in recent years and its active components as well as mechanism of action are also discussed.
引用
收藏
页数:15
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