Antibody-drug conjugates (ADCs) targeting TROP-2 in lung cancer

被引：9

作者：

Belluomini, Lorenzo ^{[1
,2
]}

Avancini, Alice ^{[1
,2
,3
]}

Sposito, Marco ^{[1
,2
]}

Milella, Michele ^{[1
,2
]}

Rossi, Antonio ^{[4
,5
]}

Pilotto, Sara ^{[1
,2
]}

机构：

[1] Univ Verona, Sch Med, Dept Med, Sect Oncol, Verona, Italy

[2] Verona Univ Hosp Trust, Verona, Italy

[3] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[4] Oncol Ctr Excellence, Therapeut Sci & Strategy Unit, Milan, Italy

[5] IQVIA, Oncol Ctr Excellence, Therapeut Sci & Strategy Unit, Milan, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2023年 / 23卷 / 11期

关键词：

ADCs; datopotamab deruxtecan; non-small cell lung cancer; small cell lung cancer; sacituzumab govitecan; TROP-2; DERUXTECAN DATO-DXD; DATOPOTAMAB DERUXTECAN; SACITUZUMAB GOVITECAN; CELL-ADHESION; PATIENTS PTS; PHASE-III; NSCLC; EXPRESSION; THERAPY; EFFICACY;

D O I：

10.1080/14712598.2023.2198087

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

IntroductionThe advent of antibody-drug conjugates (ADCs) represents a renewed strategy in the era of precision oncology. Several epithelial tumors harbor overexpression of the trophoblast cell-surface antigen 2 (TROP-2), which represents a predictor of poor prognosis and a promising target for anticancer therapy.Areas coveredIn this review, we aim to collect the available preclinical and clinical data regarding anti-TROP-2 ADCs in lung cancer obtained through extensive literature research and screening of the available abstract/posters presented at recent meetings.Expert opinionAnti-TROP-2 ADCs represent an innovative upcoming weapon against both non-small cell lung cancer and small cell lung cancer subtypes, pending the results of several ongoing trials. The proper combination and placement of this agent throughout the lung cancer treatment pathway, the identification of potentially predictive biomarkers of benefit, as well as the optimal management and impact of peculiar toxicity (i.e. interstitial lung disease) are the next questions to be answered.

引用

页码：1077 / 1087

页数：11

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