Sex-dependent multimodal response profiles to psychosocial stress

被引:7
|
作者
Kuhn, Leandra [1 ]
Noack, Hannes [2 ]
Wagels, Lisa [1 ,3 ]
Prothmann, Anna [1 ]
Schulik, Anna [1 ]
Aydin, Ece [4 ]
Nieratschker, Vanessa [2 ,5 ]
Derntl, Birgit [2 ,5 ,6 ]
Habel, Ute [1 ,3 ]
机构
[1] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Fac Med, Pauwelsstr 30, D-52074 Aachen, Germany
[2] Univ Tubingen, Med Sch, Dept Psychiat & Psychotherapy, Calwerstr 14, D-72076 Tubingen, Germany
[3] Res Ctr Julich, Inst Neurosci & Med, JARA Inst Brain Struct Funct Relationship INM 10, Wilhelm Johnen Str, D-52425 Julich, Germany
[4] Univ Tubingen, Inst Pharmaceut Sci, Pharmaceut Bio Anal, Morgenstelle 8,Haus B, D-72076 Tubingen, Germany
[5] Univ Tubingen, Werner Reichardt Ctr Integrat Neurosci, Otfried Muller Str 25, D-72076 Tubingen, Germany
[6] Univ Tubingen, Lead Res Network, Europastr 6, D-72072 Tubingen, Germany
关键词
stress; sex differences; hippocampus; cortisol; heart rate; hbkhbjb; HEART-RATE-VARIABILITY; GENDER-DIFFERENCES; HIPPOCAMPAL ACTIVATION; CORTISOL REGULATION; BRAIN ACTIVATION; REACTIVITY; CORTEX; IMPACT; TSST; AXIS;
D O I
10.1093/cercor/bhac086
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Introduction Sex differences in stress reactions are often reported in the literature. However, the sex-dependent interplay of different facets of stress is still not fully understood. Particularly in neuroimaging research, studies on large samples combining different indicators of stress remain scarce. Materials and Methods In a functional magnetic resonance imaging study, a sample of 140 healthy participants (67 females using oral contraceptives) underwent a standardized stress induction protocol, the ScanSTRESS. During the experiment, salivary cortisol and subjective ratings were obtained at multiple time points and heart rate was recorded. Results Sex differences emerged in different facets of the stress response:Women reacted with enhanced subjective feelings of stress and increases in heart rate, while men showed more pronounced neural activation in stress-related brain regions such as the inferior frontal gyrus and insula. Subjective feelings of stress and (para) hippocampal activity were negatively related in women,whereas a slightly positive association was observed in men. Discussion These results provide further insight in the sex-specific stress response patterns. Moreover, they emphasize the role of the hippocampus in the regulation of the stress response. This paves the way for the identification of sex-dependent vulnerability factors that can, in the future, be implemented in the prevention and treatment of stress-related disorders.
引用
收藏
页码:583 / 596
页数:14
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