Renal Inflammatory Myofibroblastic Tumor in an Infant: Case Report with Review of Literature

被引:0
作者
Dave, Vinayak [1 ]
Shah, Aekta [1 ]
Parambil, Badira [2 ]
Panjwani, Poonam [1 ]
Qureshi, Sajid [3 ]
Ramadwar, Mukta [1 ]
机构
[1] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Pathol, Mumbai, Maharashtra, India
[2] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Pediat Oncol, Mumbai, Maharashtra, India
[3] Homi Bhabha Natl Inst, Tata Mem Ctr, Dept Surg Oncol, Mumbai, Maharashtra, India
关键词
inflammatory myofibroblastic tumor; kidney; ALK inhibitors; KIDNEY; ALK; PSEUDOTUMOR; LYMPHOMA; CHILD;
D O I
10.1055/s-0043-1777041
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inflammatory myofibroblastic tumor (IMT) is an intermediate-grade neoplasm of myofibroblastic lineage occurring due to a cytogenetic clonal abnormality of chromosome 2p23. Pediatric renal IMTs are rare and infant renal IMTs are almost anecdotal. We herein report a 1-year-old female child who presented with a firm mass in the right lumbar region. Biopsy, and later, surgical resection revealed a tumor composed of spindle cells with intermixed plasma cells. On immunohistochemistry (IHC), the lesional cells were positive for smooth muscle actin and anaplastic lymphoma kinase (ALK). A diagnosis of IMT was made based on morphology and IHC. Diagnosis of renal IMTs become challenging especially in a tiny biopsy wherein clear cell sarcoma of kidney, Wilms tumor with predominant mesenchymal component, congenital mesoblastic nephroma, and metanephric stromal tumor are the differential diagnoses in this age group. Renal IMTs generally have better prognosis as compared to extrarenal IMTs. Approximately, 50 to 60% of these tumors harbor ALK gene rearrangement as demonstrated by positivity for ALK IHC. ALK inhibitors like crizotinib or ceritinib can be given for advanced metastatic tumors.
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共 25 条
[1]   Inflammatory myofibroblastic tumor of the kidney in a child: Report of a case [J].
Boo, Yoon-Jung ;
Kim, Jin ;
Kim, Jong-Han ;
Kim, Chong-Suk ;
Suh, Sung-Ock .
SURGERY TODAY, 2006, 36 (08) :710-713
[2]  
Brunn H., 1939, J Thorac Cardiovasc Surg, V9, P9119
[3]   ALK IHC and FISH discordant results in patients with NSCLC and treatment response: for discussion of the question-to treat or not to treat? [J].
Cabillic, Florian ;
Hofman, Paul ;
Ilie, Marius ;
Peled, Nir ;
Hochmair, Maximilian ;
Dietel, Manfred ;
Von Laffert, Maximilian ;
Gosney, John R. ;
Lopez-Rios, Fernando ;
Erb, Gilles ;
Schalles, Uwe ;
Barlesi, Fabrice .
ESMO OPEN, 2018, 3 (06)
[4]   Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor - A comparative immunohistochemical study [J].
Cook, JR ;
Dehner, LP ;
Collins, MH ;
Ma, ZG ;
Morris, SW ;
Coffin, CM ;
Hill, DA .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (11) :1364-1371
[5]   Pediatric renal inflammatory myofibroblastic tumours: A case report and review of the etiology and management options [J].
Czerwinski, Michael ;
Dave, Sumit .
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, 2012, 6 (04) :E150-E153
[6]   Inflammatory myofibroblastic tumors in children [J].
Dalton, Brian G. A. ;
Thomas, Priscilla G. ;
Sharp, Nicole E. ;
Manalang, Michelle A. ;
Fisher, James E. ;
Moir, Christopher R. ;
St Peter, Shawn D. ;
Iqbal, CoreyW. .
JOURNAL OF PEDIATRIC SURGERY, 2016, 51 (04) :541-544
[7]   Inflammatory Myofibroblastic Tumor of the Kidney and Bilateral Lung Nodules in a Child Mimicking Wilms Tumor With Lung Metastases [J].
Dogan, Mehmet S. ;
Doganay, Selim ;
Koc, Gonca ;
Gorkem, Sureyya B. ;
Unal, Ekrem ;
Ozturk, Figen ;
Coskun, Abdulhakim .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2015, 37 (06) :e390-e393
[8]   Inflammatory myofibroblastic tumor of renal pelvis presenting with prolonged fever and abdominal pain in children: report of 1 case and review of literature [J].
Ho, PH ;
Chen, SY ;
Hsueh, C ;
Lai, MW ;
Chao, HC ;
Chang, PY .
JOURNAL OF PEDIATRIC SURGERY, 2005, 40 (11) :E35-E37
[9]   PLASMA-CELL GRANULOMA OF THE RENAL PELVIS [J].
ITOH, H ;
NAMIKI, M ;
YOSHIOKA, T ;
ITATANI, H .
JOURNAL OF UROLOGY, 1982, 127 (06) :1177-1178
[10]   WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition [J].
Jo, Vickie Y. ;
Fletcher, Christopher D. M. .
PATHOLOGY, 2014, 46 (02) :95-104