Response and local control in patients treated with low-dose radiotherapy for tumoral mycosis fungoides

被引：1

作者：

Pena, Joseph ^{[1
]}

Cull, Deborah ^{[1
]}

Strowd, Lindsay C. ^{[1
]}

Vaidya, Rakhee ^{[2
]}

Seegars, Mary Beth ^{[3
]}

Ahn, Christine ^{[1
,4
]}

Winkfield, Karen M. ^{[3
]}

Hughes, Ryan T. ^{[2
]}

机构：

[1] Wake Forest Univ, Ctr Dermatol Res, Dept Dermatol, Sch Med, Winston Salem, NC USA

[2] Wake Forest Univ, Sch Med, Dept Radiat Oncol, Winston Salem, NC 27109 USA

[3] Vanderbilt Univ, Med Ctr, Dept Radiat Oncol, Nashville, TN USA

[4] Wake Forest Univ, Sch Med, Dept Pathol, Winston Salem, NC USA

来源：

LEUKEMIA & LYMPHOMA | 2023年 / 64卷 / 13期

基金：

美国国家卫生研究院;

关键词：

Cutaneous t-cell lymphoma; dermatopathology; oncology; radiation therapy; tumor; RADIATION-THERAPY; MANAGEMENT; FEATURES; STAGE;

D O I：

10.1080/10428194.2023.2254435

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Low-dose radiotherapy (LDRT), defined in this study as 2 fractions of 4 Gy delivered on consecutive days, is an effective option for local palliation of mycosis fungoides (MF), but its efficacy for tumoral lesions (TL) needs investigation. We assessed response and local control (LC) rates for patients treated with LDRT for MF and compared these outcomes between TL and non-TL. A total of 73 lesions in 18 patients treated with LDRT between 2013-2020 were analyzed. Response was defined as complete response (CR), partial response (PR), or no response (NR). In the non-TL versus TL groups, CR was observed in 16.7% v. 4.0%, PR in 81.2% v. 80.0%, NR in 2.1% v. 16.0%, respectively. 2-year LC was 100% for non-TL and 61% for TLs (p < 0.01). LDRT yields excellent response and lesion control for non-TLs and is associated with lower response rates and LC for TLs.

引用

页码：2202 / 2207

页数：6

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