Quercetin, a Flavonoid with Great Pharmacological Capacity

被引:90
作者
Carrillo-Martinez, Eber Josue [1 ]
Flores-Hernandez, Flor Yohana [1 ]
Salazar-Montes, Adriana Maria [2 ]
Nario-Chaidez, Hector Fabian [3 ]
Hernandez-Ortega, Luis Daniel [4 ]
机构
[1] Ctr Invest & Asistencia Tecnol & Diseno Estado Jal, Unidad Biotecnol Med & Farmaceut, Guadalajara 44270, Mexico
[2] Univ Guadalajara, Ctr Univ Ciencias Salud, Inst Invest Enfermedades Cron Degenerat, Sierra Mojada 950, Guadalajara 44340, Mexico
[3] Sistemas & Serv Oncol Latinoamer SA CV, Zapopan 45079, Mexico
[4] Univ Guadalajara, Ctr Univ Tonala, Ctr Invest Multidisciplinaria Salud, Tonala 45425, Mexico
基金
英国科研创新办公室;
关键词
quercetin; antioxidant; free radicals; pharmacological properties; nanoparticles; MESOPOROUS SILICA NANOPARTICLES; IN-VIVO; DELIVERY;
D O I
10.3390/molecules29051000
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Quercetin is a flavonoid with a low molecular weight that belongs to the human diet's phenolic phytochemicals and nonenergy constituents. Quercetin has a potent antioxidant capacity, being able to capture reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive chlorine species (ROC), which act as reducing agents by chelating transition-metal ions. Its structure has five functional hydroxyl groups, which work as electron donors and are responsible for capturing free radicals. In addition to its antioxidant capacity, different pharmacological properties of quercetin have been described, such as carcinostatic properties; antiviral, antihypertensive, and anti-inflammatory properties; the ability to protect low-density lipoprotein (LDL) oxidation, and the ability to inhibit angiogenesis; these are developed in this review.
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页数:31
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