Association between SARS-CoV-2 RNAemia, skewed T cell responses, inflammation, and severity in hospitalized COVID-19 people living with HIV

被引：10

作者：

Augello, Matteo ^{[1
]}

Bono, Valeria ^{[1
]}

Rovito, Roberta ^{[1
]}

Tincati, Camilla ^{[1
]}

Bianchi, Silvia ^{[2
]}

Taramasso, Lucia ^{[3
]}

Di Biagio, Antonio ^{[3
,4
]}

Callegaro, Annapaola ^{[5
,6
]}

Maggiolo, Franco ^{[7
]}

Borghi, Elisa ^{[2
]}

Monforte, Antonella d'Arminio ^{[1
]}

Marchetti, Giulia ^{[1
]}

机构：

[1] Univ Milan, San Paolo Hosp, Dept Hlth Sci, Clin Infect Dis & Trop Med,ASST Santi Paolo & Car, Milan, Italy

[2] Univ Milan, Dept Hlth Sci, Microbiol & Clin Microbiol, Milan, Italy

[3] San Martino Policlin Hosp, Infect Dis Unit, Genoa, Italy

[4] Univ Genoa, Dept Hlth Sci, Genoa, Italy

[5] ASST Papa Giovanni XXIII, Biobank Unit, Bergamo, Italy

[6] ASST Papa Giovanni XXIII, Microbiol & Virol Lab, Bergamo, Italy

[7] ASST Papa Giovanni XXIII, Div Infect Dis, Bergamo, Italy

来源：

ISCIENCE | 2024年 / 27卷 / 01期

关键词：

INFECTED PATIENTS; IMMUNE-RESPONSES; DISEASE; INTERLEUKIN-2; EXPRESSION;

D O I：

10.1016/j.isci.2023.108673

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Severe COVID-19 outcomes have been reported in people living with HIV (PLWH), yet the underlying pathogenetic factors are largely unknown. We therefore aimed to assess SARS-CoV-2 RNAemia and plasma cytokines in PLWH hospitalized for COVID-19 pneumonia, exploring associations with magnitude and functionality of SARS-CoV-2-specific immune responses. Eighteen unvaccinated PLWH (16/18 on cART; median CD4 T cell count 361.5/mu L; HIV-RNA<50 cp/mL in 15/18) and 18 age/sex-matched people without HIV were consecutively recruited at a median time of 10 days from symptoms onset. PLWH showed greater SARS-CoV-2 RNAemia, a distinct plasma cytokine profile, and worse respiratory function (lower PaO2/FiO2 nadir), all correlating with skewed T cell responses (higher perforin production by cytotoxic T cells as well as fewer and less polyfunctional SARS-CoV-2-specific T cells), despite preserved humoral immunity. In conclusion, these data suggest a link between HIV-related T cell dysfunction and poor control over SARS-CoV-2 replication/dissemination that may in turn influence COVID-19 severity in PLWH.

引用

页数：20

共 106 条

[11] Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV [J].

Bussmann, Bianca M. ;

Reiche, Sven ;

Bieniek, Bernhard ;

Krznaric, Ivanka. ;

Ackermann, Frank ;

Jassoy, Christian .

VIROLOGY, 2010, 397 (01) :7-13

[12] Regulatory T Cells as Predictors of Clinical Course in Hospitalised COVID-19 Patients [J].

Caldrer, Sara ;

Mazzi, Cristina ;

Bernardi, Milena ;

Prato, Marco ;

Ronzoni, Niccolo ;

Rodari, Paola ;

Angheben, Andrea ;

Piubelli, Chiara ;

Tiberti, Natalia .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[13] Immunophenotype and Function of CD38-Expressing CD4+ and CD8+ T Cells in HIV-Infected Patients Undergoing Suppressive Combination Antiretroviral Therapy [J].

Cannizzo, E. Stefania ;

Bellistri, Giusi M. ;

Casabianca, Anna ;

Tincati, Camilla ;

Iannotti, Nathalie ;

Barco, Ambra ;

Orlandi, Chiara ;

Monforte, Antonella d'Arminio ;

Marchetti, Giulia .

JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (09) :1511-1513

[14] Delayed engagement of host defenses enables SARS- CoV-2 viremia and productive infection of distal organs in the hamster model of COVID-19 [J].

Carrau, Lucia ;

Frere, Justin J. ;

Golynker, Ilona ;

Fajardo, Alvaro ;

Rivera, Cristobal F. ;

Horiuchi, Shu ;

Roonprapunt, Tyler ;

Minkoff, Judith M. ;

Blanco-Melo, Daniel ;

TenOever, Benjamin .

SCIENCE SIGNALING, 2023, 16 (789)

[15] SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape [J].

Cele, Sandile ;

Karim, Farina ;

Lustig, Gila ;

San, James Emmanuel ;

Hermanus, Tandile ;

Tegally, Houriiyah ;

Snyman, Jumari ;

Moyo-Gwete, Thandeka ;

Wilkinson, Eduan ;

Bernstein, Mallory ;

Khan, Khadija ;

Hwa, Shi-Hsia ;

Tilles, Sasha W. ;

Singh, Lavanya ;

Giandhari, Jennifer ;

Mthabela, Ntombifuthi ;

Mazibuko, Matilda ;

Ganga, Yashica ;

Gosnell, Bernadett, I ;

Karim, Salim S. Abdool ;

Hanekom, Willem ;

Van Voorhis, Wesley C. ;

Ndung'u, Thumbi ;

Lessells, Richard J. ;

Moore, Penny L. ;

Moosa, Mahomed-Yunus S. ;

de Oliveira, Tulio ;

Sigal, Alex .

CELL HOST & MICROBE, 2022, 30 (02) :154-+

[16] Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections [J].

Chandran, Aneesh ;

Rosenheim, Joshua ;

Nageswaran, Gayathri ;

Swadling, Leo ;

Pollara, Gabriele ;

Gupta, Rishi K. ;

Burton, Alice R. ;

Guerra-Assuncao, Jose Afonso ;

Woolston, Annemarie ;

Ronel, Tahel ;

Pade, Corinna ;

Gibbons, Joseph M. ;

De Estrada, Blanca Sanz-Magallon Duque ;

de Massy, Marc Robert ;

Whelan, Matthew ;

Semper, Amanda ;

Brooks, Tim ;

Altmann, Daniel M. ;

Boyton, Rosemary J. ;

McKnight, Aine ;

Captur, Gabriella ;

Manisty, Charlotte ;

Treibel, Thomas Alexander ;

Moon, James C. ;

Tomlinson, Gillian S. ;

Maini, Mala K. ;

Chain, Benjamin M. ;

Noursadeghi, Mahdad .

CELL REPORTS MEDICINE, 2022, 3 (03)

[17] Emergence of Multiple SARS-CoV-2 Antibody Escape Variants in an Immunocompromised Host Undergoing Convalescent Plasma Treatment [J].

Chen, Liang ;

Zody, Michael C. ;

Di Germanio, Clara ;

Martinelli, Rachel ;

Mediavilla, Jose R. ;

Cunningham, Marcus H. ;

Composto, Kaelea ;

Chow, Kar Fai ;

Kordalewska, Milena ;

Corvelo, Andre ;

Oschwald, Dayna M. ;

Fennessey, Samantha ;

Zetkulic, Marygrace ;

Dar, Sophia ;

Kramer, Yael ;

Mathema, Barun ;

Germer, Soren ;

Stone, Mars ;

Simmons, Graham ;

Busch, Michael P. ;

Maniatis, Tom ;

Perlin, David S. ;

Kreiswirth, Barry N. .

MSPHERE, 2021, 6 (04) :1-7

[18] Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019 [J].

Chen, Xiaohua ;

Zhao, Binghong ;

Qu, Yueming ;

Chen, Yurou ;

Xiong, Jie ;

Feng, Yong ;

Men, Dong ;

Huang, Qianchuan ;

Liu, Ying ;

Yang, Bo ;

Ding, Jinya ;

Li, Feng .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (08) :1937-1942

[19] Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host [J].

Choi, Bina ;

Choudhary, Manish C. ;

Regan, James ;

Sparks, Jeffrey A. ;

Padera, Robert F. ;

Qiu, Xueting ;

Solomon, Isaac H. ;

Kuo, Hsiao-Hsuan ;

Boucau, Julie ;

Bowman, Kathryn ;

Das Adhikari, U. ;

Winkler, Marisa L. ;

Mueller, Alisa A. ;

Hsu, Tiffany Y. -T. ;

Desjardins, Michael ;

Baden, Lindsey R. ;

Chan, Brian T. ;

Walker, Bruce D. ;

Lichterfeld, Mathias ;

Brigl, Manfred ;

Kwon, Douglas S. ;

Kanjilal, Sanjat ;

Richardson, Eugene T. ;

Jonsson, A. Helena ;

Alter, Galit ;

Barczak, Amy K. ;

Hanage, William P. ;

Yu, Xu G. ;

Gaiha, Gaurav D. ;

Seaman, Michael S. ;

Cernadas, Manuela ;

Li, Jonathan Z. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (23) :2291-2293

[20] SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms [J].

Clark, Sarah A. ;

Clark, Lars E. ;

Pan, Junhua ;

Coscia, Adrian ;

McKay, Lindsay G. A. ;

Shankar, Sundaresh ;

Johnson, Rebecca, I ;

Brusic, Vesna ;

Choudhary, Manish C. ;

Regan, James ;

Li, Jonathan Z. ;

Griffiths, Anthony ;

Abraham, Jonathan .

CELL, 2021, 184 (10) :2605-+

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