Bringing immunofocusing into focus

被引：17

作者：

Musunuri, Sriharshita ^{[1
,2
]}

Weidenbacher, Payton A. B. ^{[1
,3
]}

Kim, Peter S. ^{[1
,2
,4
]}

机构：

[1] Stanford Univ, Stanford ChEM H, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[4] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

来源：

NPJ VACCINES | 2024年 / 9卷 / 01期

关键词：

NEUTRALIZING ANTIBODY-RESPONSES; ORIGINAL ANTIGENIC SIN; INFLUENZA-VIRUS HEMAGGLUTININ; CD4; BINDING-SITE; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; STRUCTURAL INSIGHTS; IMMUNE-RESPONSE; CELL RESPONSES; V3; LOOP;

D O I：

10.1038/s41541-023-00792-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunofocusing is a strategy to create immunogens that redirect humoral immune responses towards a targeted epitope and away from non-desirable epitopes. Immunofocusing methods often aim to develop "universal" vaccines that provide broad protection against highly variant viruses such as influenza virus, human immunodeficiency virus (HIV-1), and most recently, severe acute respiratory syndrome coronavirus (SARS-CoV-2). We use existing examples to illustrate five main immunofocusing strategies-cross-strain boosting, mosaic display, protein dissection, epitope scaffolding, and epitope masking. We also discuss obstacles for immunofocusing like immune imprinting. A thorough understanding, advancement, and application of the methods we outline here will enable the design of high-resolution vaccines that protect against future viral outbreaks.

引用

页数：11

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