Safety and efficacy of CT-guided percutaneous microwave ablation for stage I non-small cell lung cancer in patients with comorbid idiopathic pulmonary fibrosis

被引:4
作者
Peng, JinZhao [1 ,2 ]
Bie, ZhiXin [1 ]
Li, YuanMing [1 ]
Guo, RunQi [1 ]
Li, XiaoGuang [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Dept Minimally Invas Tumor Therapies Ctr, Natl Ctr Gerontol, Beijing Hosp,Inst Geriatr Med, 1 Dongdan Dahua St, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci, Grad Sch, Peking Union Med Coll, Beijing 100370, Peoples R China
关键词
Microwaves; Non-small cell lung cancer; Idiopathic pulmonary fibrosis; Safety; Survival; BODY RADIATION-THERAPY; RADIOFREQUENCY ABLATION; AMERICAN-COLLEGE; SURVIVAL; IMPACT; RESECTION; SOCIETY; PNEUMONITIS; DISEASE; RISK;
D O I
10.1007/s00330-023-10510-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objectives To evaluate the safety and efficacy of microwave ablation (MWA) for stage I non-small cell lung cancer (NSCLC) in patients with idiopathic pulmonary fibrosis (IPF).Materials and methods A retrospective single-center cohort study was conducted in patients with clinical stage I NSCLC who underwent CT-guided MWA from Nov 2016 to Oct 2021. The patients were divided into the IPF group and the non-IPF group. The primary endpoints were 90-day adverse events and hospital length of stay (HLOS). The secondary endpoints included overall survival (OS) and progression-free survival (PFS).Results A total of 107 patients (27 with IPF and 80 without IPF) were finally included for analysis. No procedure-related acute exacerbation of IPF or death occurred post-MWA. The rates of adverse events were similar between the groups (48.6% vs. 47.7%; p = 0.998). The incidence of grade 3 adverse events in the IPF group was higher than that in the non-IPF group without a significant difference (13.5% vs. 4.6%; p = 0.123). Median HLOS was 5 days in both groups without a significant difference (p = 0.078). The 1-year and 3-year OS were 85.2%/51.6% in the IPF group, and 97.5%/86.4% in the non-IPF group. The survival of patients with IPF was significantly poorer than the survival of patients without IPF (p < 0.001). There was no significant difference for PFS (p = 0.271).Conclusion MWA was feasible in the treatment of stage I NSCLC in patients with IPF. IPF had an adverse effect on the survival of stage I NSCLC treated with MWA.Clinical relevance statement CT-guided microwave ablation is a well-tolerated and effective potential alternative treatment for stage I non-small cell lung cancer in patients with idiopathic pulmonary fibrosis.
引用
收藏
页码:4708 / 4715
页数:8
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