The Impact of Fibrinogen to Prognostic Nutritional Index Rate on Prognosis of Pancreatic Ductal Adenocarcinoma

被引：2
作者：
Igarashi, Yosuke [1 ]
Shirai, Yoshihiro [1 ,2 ]
Tanji, Yoshiaki [1 ]
Hamura, Ryoga [1 ]
Yanagaki, Mitsuru [1 ]
Abe, Kyohei [1 ]
Onda, Shinji [1 ]
Furukawa, Kenei [1 ]
Matsumoto, Michinori [1 ]
Tsunematsu, Masashi [1 ]
Ikegami, Toru [1 ]
机构：
[1] Jikei Univ, Sch Med, Dept Surg, Div Hepatobiliary & Pancreas Surg, Tokyo, Japan
[2] Jikei Univ, Sch Med, 3-25-8 Nishi Shinbashi, Minato Ku, Tokyo 1058461, Japan
来源：
AMERICAN SURGEON | 2023年 / 89卷 / 11期
基金：
日本学术振兴会;
关键词：
pancreatic cancer; prognostic nutritional index; fibrinogen; tumor microenvironment; prognosis; PREOPERATIVE PLATELET; CANCER; LYMPHOCYTE;
D O I：
10.1177/00031348231204912
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Introduction: The aim of the present study was to evaluate the prognostic value of the ratio of serum fibrinogen to prognostic nutritional index (PNI; Fbg/PNI) in patients undergoing resection for pancreatic ductal adenocarcinoma.Methods: A total of 140 patients who had undergone resection for pancreatic cancer were included. Patients were divided into two groups according to a Fbg/PNI >= 8.8 or <8.8. Survival data were analyzed using the log-rank test for univariate analysis and Cox proportional hazards for multivariate analysis.Results: Fbg/PNI was a significant prognostic indicator in univariate analysis for overall survival (OS) and disease-free survival (DFS). Fbg/PNI retained significance in multivariate analysis for OS (hazard ratio, 1.81; 95% confidence interval, 1.19-2.77; P < .01) in addition to tumor differentiation and nodal involvement. Fbg/PNI was a significant independent prognostic indicator of poor DFS on multivariate analysis (hazard ratio, 1.54; 95% confidence interval, 1.05-2.26; P = .03).Conclusion: Preoperative Fbg/PNI is a novel significant independent prognostic indicator for OS and DFS following resection of pancreatic cancer with curative intent.
引用
收藏
页码：4255 / 4261
页数：7
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