Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome

被引:5
作者
Butnariu, Lacramioara Ionela [1 ]
Gorduza, Eusebiu Vlad [1 ]
Tarca, Elena [2 ]
Panzaru, Monica-Cristina [1 ]
Popa, Setalia [1 ]
Stoleriu, Simona [3 ]
Lupu, Vasile Valeriu [4 ]
Lupu, Ancuta [4 ]
Cojocaru, Elena [5 ]
Trandafir, Laura Mihaela [4 ]
Moisa, Stefana Maria [4 ]
Florea, Andreea [1 ]
Statescu, Laura [6 ]
Badescu, Minerva Codruta [7 ,8 ]
机构
[1] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Med Genet, Iasi 700115, Romania
[2] Grigore T Popa Univ Med & Pharm, Dept Surg Pediat Surg 2, Iasi 700115, Romania
[3] Grigore T Popa Univ Med & Pharm, Fac Dent Med, Fixed Prosthesis Dept, Iasi 700115, Romania
[4] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Pediat, Iasi 700115, Romania
[5] Grigore T Popa Univ Med & Pharm, Dept Morphofunct Sci 1, Iasi 700115, Romania
[6] Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 3, Iasi 700115, Romania
[7] St Spiridon Cty Emergency Clin Hosp, Internal Med Clin 3, 1 Independence Blvd, Iasi 700111, Romania
[8] Grigore T Popa Univ Med & Pharm, Dept Internal Med, Iasi 700115, Romania
关键词
atherogenic dyslipidemia; metabolic syndrome; cholesterol; triglyceride; genetic risk factors; GWAS; CORONARY-ARTERY-DISEASE; LIPOPROTEIN-LIPASE GENE; ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; FAMILIAL COMBINED HYPERLIPIDEMIA; BLOOD-PRESSURE LEVELS; APOLIPOPROTEIN-E GENE; LIPID-LOWERING DRUGS; MIDDLE-AGED MEN; INSULIN-RESISTANCE; ADIPONECTIN GENE;
D O I
10.3390/diagnostics13142348
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Atherogenic dyslipidemia plays a critical role in the development of metabolic syndrome (MetS), being one of its major components, along with central obesity, insulin resistance, and hypertension. In recent years, the development of molecular genetics techniques and extended analysis at the genome or exome level has led to important progress in the identification of genetic factors (heritability) involved in lipid metabolism disorders associated with MetS. In this review, we have proposed to present the current knowledge related to the genetic etiology of atherogenic dyslipidemia, but also possible challenges for future studies. Data from the literature provided by candidate gene-based association studies or extended studies, such as genome-wide association studies (GWAS) and whole exome sequencing (WES,) have revealed that atherogenic dyslipidemia presents a marked genetic heterogeneity (monogenic or complex, multifactorial). Despite sustained efforts, many of the genetic factors still remain unidentified (missing heritability). In the future, the identification of new genes and the molecular mechanisms by which they intervene in lipid disorders will allow the development of innovative therapies that act on specific targets. In addition, the use of polygenic risk scores (PRS) or specific biomarkers to identify individuals at increased risk of atherogenic dyslipidemia and/or other components of MetS will allow effective preventive measures and personalized therapy.
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页数:36
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