BPI-472372: a potent and orally bioavailable small molecule inhibitor of CD73 for cancer immunotherapy

被引:0
|
作者
Han, Han
Yang, Xiaofeng
Zhao, Ying
Wang, Jin
Yang, Xiang
Ju, Xuepeng
Zhao, Jiayu
Zou, Zhengyao
Chen, Haibo
Liu, Xiaoyun
Guo, Jing
Yang, Cheng
Lan, Hong
Wu, Hao
Ding, Lieming
Wang, Jiabing
机构
关键词
D O I
10.1158/1538-7445.AM2023-504
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
504
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Novel, potent and orally bioavailable small molecule CD73 inhibitors for cancer immunotherapy.
    Venkateshappa, Chandregowda
    Narayanan, Kishore
    Kothandaraman, Prasath
    Priyadarshani, Garima
    Nair, Rashmi
    Goyal, Megha
    Ahuja, Vijay Kamal
    Dadhania, Sagar
    Aravind, A. B.
    Samiulla, D. S.
    Daginakkatte, Girish
    Antony, Thomas
    Nellore, Kavitha
    Panigrahi, Sunil
    Chikkanna, Dinesh
    Samajdar, Susanta
    Ramachandra, Murali
    CANCER RESEARCH, 2021, 81 (13)
  • [2] Progress towards orally bioavailable, potent, and selective small-molecule inhibitors of CD73 for cancer immunotherapy
    Lindsey, E.
    Lawson, K.
    Thomas-Tran, R.
    Beatty, J.
    Fournier, J.
    Mandal, D.
    Yan, X.
    Drew, S.
    Jeffrey, J.
    Walker, N.
    Straeter, N.
    Moschuetz, S.
    Chen, A.
    Tan, J.
    Jin, L.
    Walters, M.
    Young, S.
    Schindler, U.
    Leleti, M.
    Powers, J.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E93 - E93
  • [3] Progress towards orally bioavailable, potent, and selective small-molecule inhibitors of CD73 for immunooncology
    Thomas-Tran, Rhiannon
    Lindsey, Erick
    Lawson, Kenneth
    Beatty, Joel
    Jeffrey, Jenna
    Fournier, Jeremy
    Mandal, Debashis
    Yan, Xuelei
    Drew, Samuel
    Walker, Nigel
    Moschuetz, Susanne
    Straeter, Norbert
    Chen, Ada
    Leleti, Manmohan Reddy
    Powers, Jay
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [4] Reversal of adenosine-mediated immune suppression by CB-708, an orally bioavailable and potent small molecule inhibitor of CD73
    Lee, Clarissa C.
    Bhupathi, Deepthi
    Billedeau, Roland J.
    Chen, Jason
    Chen, Lijing
    Emberley, Ethan D.
    Gross, Matthew I.
    Huang, Tony
    Li, Weiqun
    Ma, Yong
    Mackinnon, Andrew L.
    Makkouk, Amani
    Marguier, Gisele M.
    Neou, Silinda
    Parlati, Francesco
    Sotirovska, Natalija
    Stanton, Timothy F.
    Steggerda, Susanne M.
    Zhang, Jing
    Zhang, Winter
    Li, Jim
    CANCER RESEARCH, 2019, 79 (13)
  • [5] Discovery and characterization of AB680, a potent and selective small-molecule CD73 inhibitor for cancer immunotherapy
    Lawson, Kenneth V.
    Jin, Lixia
    Jeffrey, Jenna L.
    Kalisiak, Jarek
    Yin, Fangfang
    Zhang, Kristen
    Chen, Ada
    Swinarski, Debbie
    Walters, Matt J.
    Young, Steve
    Schindler, Ulrike
    Jay, Powers P.
    CANCER RESEARCH, 2018, 78 (13)
  • [6] CB-708, an orally bioavailable small molecule inhibitor of CD73 with immunostimulatory and anti-tumor activity
    Lee, Clarissa
    Bhupathi, Deepthi
    Billedeau, Roland
    Chen, Jason
    Chen, Lijing
    Dang, Rosalyn
    Gross, Matthew
    Huang, Tony
    Li, Weiqun
    Ma, Yong
    MacKinnon, Andrew
    Marguier, Gisele
    Neou, Silinda
    Parlati, Francesco
    Sotirovska, Natalija
    Spurlock, Sandra
    Stanton, Timothy
    Steggerda, Susanne
    Zhang, Jing
    Zhang, Winter
    Li, Jim
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [7] Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production
    Du, Xiaohui
    Moore, Jared
    Blank, Brian R.
    Eksterowicz, John
    Sutimantanapi, Dena
    Yuen, Natalie
    Metzger, Todd
    Chan, Brenda
    Huang, Tom
    Chen, Xi
    Chen, Yuping
    Duong, Frank
    Kong, Wayne
    Chang, Jae H.
    Sun, Jessica
    Zavorotinskaya, Tatiana
    Ye, Qiuping
    Junttila, Melissa R.
    Ndubaku, Chudi
    Friedman, Lori S.
    Fantin, Valeria R.
    Sun, Daqing
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (18) : 10433 - 10459
  • [8] Discovery of AB680: A potent and selective CD73 inhibitor for cancer immunotherapy
    Lawson, Kenneth
    Kalisiak, Jarek
    Lindsey, Erick
    Newcomb, Eric
    Sharif, Ehesan
    Miles, Dillon
    Jeffrey, Jenna
    Leleti, Manmohan Reddy
    Chen, Ada
    Jin, Lixia
    Tan, Joanne
    Schindler, Uli
    Young, Steve
    Jaen, Juan
    Powers, Jay
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [9] Discovery and characterization of potent and selective small-molecule inhibitors of ecto-nucleotidase CD73 for cancer immunotherapy
    Lawson, K.
    Kalisiak, J.
    Lindsey, E.
    Newcomb, E.
    Rosen, B.
    Walker, N.
    Jin, L.
    Scaletti, E.
    Strater, N.
    Chen, A.
    Tan, J.
    Walters, M. J.
    Young, S.
    Schindler, U.
    Leleti, M.
    Powers, J. P.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E93 - E93
  • [10] Discovery and characterization of potent and selective small-molecule inhibitors of ecto-nucleotidase CD73 for cancer immunotherapy
    Sharif, Ehesan
    Lawson, Kenneth
    Kalisiak, Jarek
    Lindsey, Erick
    Newcomb, Eric
    Rosen, Brandon
    Walker, Nigel
    Jin, Lixia
    Scaletti, Emma
    Straeter, Norbert
    Chen, Ada
    Leleti, Manmohan Reddy
    Powers, Jay
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257