Nickel-Catalyzed Intramolecular Dearomative Arylation of Pyridiniums and Quinoliniums

被引：2

作者：

Lu, Jun ^{[1
]}

Li, Qichuang ^{[1
]}

Liang, Renxiao ^{[1
]}

Jia, Yixia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 05期

基金：

中国国家自然科学基金;

关键词：

pyridine; quinoline; arylation; dearomatization; nickel; POVAROV REACTION; ENANTIOSELECTIVE ARYLATION; ASYMMETRIC-SYNTHESIS; DERIVATIVES; AMINATION; ALKYNES;

D O I：

10.6023/cjoc202302016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed intramolecular dearomative arylation reaction of pyridiniums and quinoliniums is developed. In the presence of zinc powder as a reducing agent, the intramolecular Grignard-type addition of arylbromides to the C=N bonds of pyridiniums and quinoliniums proceeds smoothly to render pyridines and quinolines dearomatization, leading to a range of spirooxindole derivatives bearing dihydropyridine and dihydroquinoline moieties in moderate to good yields.

引用

页码：1875 / 1882

页数：8

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