Delayed normalization of C-Reactive protein and erythrocyte sedimentation rate was not associated with inferior clinical outcomes after total knee arthroplasty

被引:2
|
作者
Choi, Yun Seong [1 ]
Oh, Jong Byung [2 ]
Chang, Moon Jong [2 ]
Kim, Tae Woo [2 ]
Kang, Kee Soo [3 ]
Kang, Seung-Baik [2 ]
机构
[1] Vet Hlth Serv Med Ctr, Dept Orthoped Surg, Seoul, South Korea
[2] Seoul Natl Univ, SMGSNU Boramae Med Ctr, Dept Orthoped Surg, Coll Med, 5 Gil 20,Boramae Rd, Seoul 07061, South Korea
[3] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Orthoped Surg, Coll Med, Seoul, South Korea
基金
新加坡国家研究基金会;
关键词
C-reactive protein; Erythrocyte sedimentation rate; Periprosthetic joint infection; Unilateral total knee arthroplasty; Bilateral total knee arthroplasty; PERIPROSTHETIC JOINT INFECTION; INFLAMMATORY RESPONSE; DIAGNOSIS; HIP; SONICATION; MARKERS; VALUES; CRP;
D O I
10.1016/j.jos.2022.02.007
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Background: The purpose of this study aimed to identify the proportion of patients with delayed normalization of C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) after TKA, to determine postoperative thresholds predictive of prolonged elevation. Further, we aimed to determine if the clinical outcomes of patients with prolonged elevation were inferior to those without prolonged elevation.Methods: The records of 211 unilateral and 320 bilateral TKA were reviewed. Patients were divided into the normal and elevation group based on CRP and ESR levels at 6 weeks and 3 months. The temporal pattern of CRP and ESR change in both groups was compared, and thresholds predictive of elevation at 6 weeks and 3 months were identified. Further, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index and Tegner activity scale of both groups at 6 months, 1 year, and 2 years after TKA were compared.Results: The proportion of patients with elevated CRP and ESR at 6 weeks and 3 months was CRP: 24.2%, 10%, ESR: 51.6%, 29.9% in unilateral and CRP: 31.5%, 10.6%, ESR: 58.1%, 42.7% in bilateral TKA. The thresholds for elevation at 6 weeks and 3 months were 9.5 mg/dL, 11.4 mg/dL (CRP at 6 weeks) and 81.5 mm/h, 74.5 mm/h (ESR at 3 months). There was no difference in the WOMAC score and Tegner activity scale between both groups.Conclusions: CRP and ESR are often elevated for a prolonged period even in the absence of infection after TKA. Such cases show distinct temporal patterns, which are predictable, and do not appear to have a significant effect on clinical outcome (c) 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:589 / 596
页数:8
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